ALKYLATION DE QUELQUES COMPOSES CARBONYLES PAR DES GROUPES TERTIAIRES. UTILISATION DE LA REACTION DE FRIEDEL-CRAFTS DANS LA SYNTHESE D'ESTERS ET DE CETONES ENCOMBRES
t-Alkylation of carboxylic esters via their ketene alkyl trimethylsilyl acetels by the Friedel-Crafts reaction allows the synthesis of new higly hindered compounds.A new route using sodium amide in dimethoxyethane, for the preparation of trimethylsilyl enol ethers of ketones, is described.The α-butylation of these compounds permits the synthesis of new crowded pentasubstituted ketones.The limits as well as the performance of the method have been studied.
Lion, Claude,Dubois, Jacques-Emile
p. 319 - 323
(2007/10/02)
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