cas 54474-50-9, 2,4-DIMETHYL-3-PYRROLEPROPIONIC ACID | Articles data ｜lookchem

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54474-50-9

Articles about 54474-50-9Total 6 be found

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Boradiazaindacene dyes for technology of biological microchips
A number of boradiazaindacene dyes containing a carboxyl group separated from a fluorophore by two methylene units were synthesized. The compounds have narrow spectral bands with absorption maxima at 480-530 nm and fluorescence maxima at 500-550 nm. Succinimide esters of these compounds and the corresponding fluorescent-labeled oligonucleotides were also prepared. Boradiazaindacene dyes can be used as fluorescent labels for oligonucleotides for analysis of melting curves of duplexes on microchips either by themselves or in combination with Texas Red. They can also be applied for labeling primers for polymerase chain reaction.
Belobritskaya,Neunylova,Vasiliskov,Rumyantseva,Chudinov,Zasedatelev
p. 617 - 619
(2007)
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FORMULATIONS FOR PHARMACEUTICAL AGENTS IONIZABLE AS FREE ACIDS OR FREE BASES
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Page/Page column 213-214

(2008/06/13)

5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
The present invention relates to 5-sulfonamido substituted indolinones that modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
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Page/Page column 16-17

(2010/02/08)

Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)
The present invention relates generally to the field of radiosensitizing agents which are capable of enhancing radiotherapy by inhibiting DNA-PK (DNA-protein kinase). In particular, it relates to sulfonamide substituted indolinones which inhibit DNA-PK.
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Page 12

(2010/02/10)

Pyrrole substituted 2-indolinone protein kinase inhibitors
The present invention relates to novel pyrrole substituted 2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
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(2008/06/13)

Bromination of Dipyrromethenes for Porphyrin Synthesis
5'-Bromo-5-(bromomethyl)-2,2'-dipyrromethenium bromides (1) and dimers were prepared in 90percent yield from 5'-unsubstituted (16), 5'-carboxy- (15),or 5'-bromo-5-methyl-2,2'-dipyrromethenium bromides (17) by treatment of the latter with bromine and trifluoroacetic acid in chlorocarbon solvents at room temperature.Dipyrromethenes (1) are important intermediates in the Johnson regioselective synthesis of porphyrins via biladienes (3).Improvements in porphyrin synthetic methodology are exemplified by the preparation of etioporphyrin III (4a) and mesoporphyrin II dimethyl ester (4b)
Paine, John B.,Hiom, John,Dolphin, David
p. 2796 - 2802
(2007/10/02)

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Chemical Properties

Melting Point: 140-141 °C
Boiling Point: 332.8 °C at 760 mmHg
Flash Point:155.1 °C
Density: 1.159 g/cm³
Storage Temp.:Sealed in dry,Room Temperature
Vapor Pressure: 5.67E-05mmHg at 25°C
Refractive Index: 1.551
PKA: 4.68±0.10(Predicted)
PSA: 53.09000
LogP: 1.64870

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