- A novel pathway for the thermolysis of N-nitrosoanthranilates using flash vacuum pyrolysis leading to 7-aminophthalides
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Flash vacuum pyrolysis of methyl N-methyl-N-nitrosoanthranilate leads to elimination of nitric oxide and disproportionation of the formed N-radical to 7-(methylamino)phthalide and methyl N-methylanthranilate. This transformation was found to be a convenient, solvent-free method for the preparation of 7-(methylamino)phthalides. An alternative route through pyrolysis of N-benzyl-N-methyl anthranilates was also investigated. This journal is
- Dallinger, Doris,Kappe, C. Oliver,Zlatkovi?, Dragan
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supporting information
p. 8371 - 8375
(2020/11/05)
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- Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents
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A total of 29 novel sulfenamide compounds were synthesized, spectroscopically characterized and evaluated in vitro for antimicrobial activity against various infectious pathogens. Compounds 1b and 2c exhibited potent inhibition against clinical Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentration (MIC) values of 1.56 μg/mL.
- Shang, Jian-Li,Guo, Hui,Li, Zai-Shun,Ren, Biao,Li, Zheng-Ming,Dai, Huan-Qin,Zhang, Li-Xin,Wang, Jian-Guo
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supporting information
p. 724 - 727
(2013/02/25)
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- Synthesis and biological evaluation of nonsymmetrical aromatic disulfides as novel inhibitors of acetohydroxyacid synthase
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46 Novel nonsymmetrical aromatic disulfides containing [1,3,4]thiadiazole or [1,3,4]oxadiazole groups were synthesized and their biological activities were evaluated as inhibitors of acetohydroxyacid synthase (AHAS, EC 2.2.1.6). Besides their strong in vitro inhibition against plant AHAS, compounds 3e and 3f also display 80-100% post-emergence herbicidal activities in greenhouse bioassay at 1500 g/ha dosage. The assay of exogenous branched-chain amino acids supplementation on rape root growth of 3e suggests that the herbicidal activity has relationship with AHAS inhibition.
- Li, Zai-Shun,Wang, Wei-Min,Lu, Wei,Niu, Cong-Wei,Li, Yong-Hong,Li, Zheng-Ming,Wang, Jian-Guo
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supporting information
p. 3723 - 3727
(2013/07/25)
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- Synthesis and biological evaluation of sulfur-containing cinnamate and salicylate derivatives
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UV irradiation induced formation of reactive oxygen radical species and matrix metalloproteinases (MMPs) are thought to be involved in photo-damage to the skin. MMP-1 is the major collagenolytic enzyme responsible for collagen destruction in skin tissue. To develop new anti-photoaging agents, a series of 2,2′-dithiocinnamate derivatives and 2,2′-dithio or 2-thiobenzoate derivatives were designed and synthesized. The biological activities of the synthesized compounds were assayed for ABTS [2,2′-azinobis-(3-ethyl-benzo- thiazoline-6-sulfonic acid)] radical scavenging activity, MMP-1 inhibitory activity, and cytotoxicity to human dermal fibroblast cells. Compounds with potential of resistance to UV irradiation were identified. These compounds are expected to be useful for preventing photo-damage to the skin.
- Chiang, Chih-Chia,Chang, Tsu-Chung,Tsai, Hou-Jen,Hsu, Ling-Yih
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p. 369 - 373
(2008/09/20)
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- N-(2-Alkoxycarbonylbenzenesulfeny)benzimidazoles as nitrogen-, sulfur-, and carbon-sulfenylation reagents
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N-(2-Alkoxycarbonylbenzenesulfenyl)benzimidazoles reacted with nucleophiles such as amides, imidates, thiols, Grignard reagents, and active methylene compounds to yield the corresponding sulfenylated products: N-acylsulfenamides, N-sulfenylimidates, disulfides, sulfides, and sulfenylated active methylene compounds, respectively.
- Shimizu, Masao,Fukazawa, Hidenori,Inoue, Jun'ichi,Abe, Yoshimoto,Konakahara, Takeo
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- A direct preparation of functionalized aryl and heteroaryl disulfides from functionalized zinc organometallics by using sulfur monochloride (S 2Cl2)
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A range of functionalized aryl and heteroaryl disulfides has been prepared from zinc organometallics by using sulfur monochloride (S2Cl 2). The zinc reagents were obtained by transmetalation from magnesium or lithium reagents with ZnBr2.
- Korn, Tobias J.,Knochel, Paul
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p. 1185 - 1187
(2007/10/03)
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- Some Reactions of 3,1-Benzoxathian-4-ones
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3,1-Benzoxathian-4-ones (II) have been thiated with Lawesson reagent (I) and also with P4S10 to give a mixture of IV, V and VI.These thianones (II) react too with Grignard reagents to give 4-alkyl/aryl-2-phenyl-3,1-benzoxathian-4-ols (VIII), and with alkoxides and mercaptides to give bis(2-substituted phenyl) disulphides (IX). 2-Phenyl-1, 3-benzodithiane-4-thione (Vc) reacts with primary amines and hydrazines to give the imino and hydrazono derivatives (X).The reactions of Vc with diphenyl diazomethane, diazofluorene and copper-bronze have also been studied.
- El-Barbary, A. A.,Hammouda, H. A.,El-Borai, M.
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p. 770 - 773
(2007/10/02)
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- Electrochemically Induced Homogeneous Electron Transfer to Aromatic Disulfides
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The rate constant of the heterogeneous electron transfer from a platinum electrode to aromatic disulfides is low, whereas the homogeneous electron transfer from suitable aromatic anion radicals is much faster.Anion radicals of such aromatic compounds can thus be generated electrochemically at potentials more negative than the normal standard reduction potential of the disulfide, but less negative than its observed reduction potential.An attempt is made to estimate E0 of the aromatic disulfides from the rates of the homogeneous electron transfer from a number of donors and the reversible redox potential of these donors.
- Simonet, Jacques,Carriou, Michel,Lund, Henning
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p. 1665 - 1673
(2007/10/02)
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