545423-95-8

Basic information

• Product Name: 2-(quinolin-3-yl)acetaldehyde
• Synonyms: 2-(quinolin-3-yl)acetaldehyde
• CAS NO: 545423-95-8
• Molecular Formula: C11H9NO
• Molecular Weight: 171.2
• Mol File: 545423-95-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(quinolin-3-yl)acetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(quinolin-3-yl)acetaldehyde(545423-95-8)
• EPA Substance Registry System: 2-(quinolin-3-yl)acetaldehyde(545423-95-8)

Safety Data

• Hazardous Substances Data: 545423-95-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(quinolin-3-yl)acetaldehyde is used as a key intermediate in the production of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its chemical structure allows for the creation of a wide range of compounds with potential medicinal properties.
Used in Agrochemical Production:
In the agrochemical industry, 2-(quinolin-3-yl)acetaldehyde is employed as a precursor in the synthesis of various agrochemicals, such as pesticides and herbicides. Its role in these applications is to provide a foundation for the creation of effective and targeted chemical solutions for agricultural use.
Used in Specialty Chemicals:
2-(quinolin-3-yl)acetaldehyde is utilized as a building block in the synthesis of specialty chemicals, which are often used in niche applications across various industries. Its versatility in chemical reactions makes it a valuable component in the development of these specialized products.
Used in Medicinal and Chemical Research:
2-(quinolin-3-yl)acetaldehyde is used as a subject of study in medicinal and chemical research, where its potential biological activity is explored. Researchers investigate its interactions with biological systems to understand its possible applications in the development of new treatments and therapies.

Upstream product

• 13669-42-6 3-quinolylcarboxaldehyde 

Relevant articles and documents

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents

Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs endowed with diverse mechanistic properties. Benzoxazepines were recently identified as a novel class of MTAs. These anticancer agents were thoroughly characterized for their antitumor activity, although, their exact mechanism of action remained elusive. Combining chemical, biochemical, cellular, bioinformatics and structural efforts we developed improved pyrrolonaphthoxazepines antitumor agents and their mode of action at the molecular level was elucidated. Compound 6j, one of the most potent analogues, was confirmed by X-ray as a colchicine-site MTA. A comprehensive structural investigation was performed for a complete elucidation of the structure-activity relationships. Selected pyrrolonaphthoxazepines were evaluated for their effects on cell cycle, apoptosis and differentiation in a variety of cancer cells, including multidrug resistant cell lines. Our results define compound 6j as a potentially useful optimized hit for the development of effective compounds for treating drug-resistant tumors.

4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.