- METHOD FOR PRODUCING epsilon-CAPROLACTAM
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The present invention is a method of producing ε-caprolactam through adipamide as an intermediate, and characteristically includes a lactamization step of reacting adipamide, formed from a material compound, with hydrogen and ammonia in the presence of a catalyst containing: a metal oxide mainly containing an oxide(s) of one or more metallic elements selected from the group consisting of metallic elements of group 5 and groups 7 to 14 in the 4th to 6th periods of the periodic table; and a metal and/or a metal compound having a hydrogenation ability. The method can increase the selectivity of ε-caprolactam.
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Paragraph 0096
(2020/03/09)
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- Method for producing 3-oxoadipic acid
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A method of producing 3-oxoadipic acid from an aliphatic compound easily utilizable by a microorganism, such as a saccharide, by utilization of a metabolic pathway of the microorganism is disclosed. The method of producing 3-oxoadipic acid includes the step of culturing at least one type of microorganism having a capacity to produce 3-oxoadipic acid, selected from the group consisting of, for example, microorganisms belonging to the genus Serratia, microorganisms belonging to the genus Corynebacterium, microorganisms belonging to the genus Hafnia, microorganisms belonging to the genus Bacillus, microorganisms belonging to the genus Escherichia, microorganisms belonging to the genus Pseudomonas, microorganisms belonging to the genus Acinetobacter, microorganisms belonging to the genus Alcaligenes, microorganisms belonging to the genus Shimwellia, microorganisms belonging to the genus Planomicrobium, microorganisms belonging to the genus Nocardioides, microorganisms belonging to the genus Yarrowia, microorganisms belonging to the genus Cupriavidus, microorganisms belonging to the genus Rhodosporidium, microorganisms belonging to the genus Streptomyces, and microorganisms belonging to the genus Microbacterium.
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Page/Page column 11-12
(2020/12/18)
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- A 5 - amino acetyl propionic acid hydrochloride intermediate environmental preparation method
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The invention discloses a 5 - amino acetyl propionic acid hydrochloride intermediate environmental preparation method, the method using a compound represented by the structural formula I and II shown in the structural formula of the compound as a raw material, wherein R1 , R2 , R3 Represents hydrogen, methyl, ethoxy or methoxy, R4 Represents hydrogen, potassium or sodium, by condensation reaction and supported bi-reaction to obtain 5 - amino acetyl propionic acid hydrochloride salt intermediate. The preparation method is simple, the reaction process and after-reaction of the post-treatment process to avoid the use of water, the washing process without need of extraction, high yield, compared with the traditional method, greatly reduces the production of waste water, more green environmental protection, is favorable for industrial production.
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Paragraph 0021-0023; 0025-0027
(2019/07/01)
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- METHOD OF PRODUCING EPSILON-CAPROLACTAM
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A method of producing ε-caprolactam from 3-oxoadipic acid includes: step 1 of mixing at least one selected from the group consisting of 3-oxoadipic acid and salts thereof with a catalyst and a solvent in the presence of hydrogen to produce 3-hydroxyadipic acid; and step 2 of reacting the 3-hydroxyadipic acid which is a product of step 1, a salt or carboxylic acid derivative thereof, or a mixture of these with hydrogen and ammonia.
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Paragraph 0074
(2018/09/12)
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- Preparation methods for 5-aminolevulinic acid hydrochloride and 5-aminolevulinic acid hydrochloride intermediate
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The invention discloses preparation methods for a 5-aminolevulinic acid hydrochloride and a 5-aminolevulinic acid hydrochloride intermediate. The preparation method for the 5-aminolevulinic acid hydrochloride intermediate comprises: (1) carrying out a reaction on a compound 2 and isopropylidene malonate in an organic solvent under the actions of an organic alkali and a condensing agent to obtain acompound 3; and (2) carrying out a reaction on the compound 3 in a C1-C4 alcohol solvent to obtain a compound 4, wherein R1 and R' are respectively and independently C1-C4 alkyl. The present invention further provides a method for preparing a 5-aminolevulinic acid hydrochloride by using the 5-aminolevulinic acid hydrochloride intermediate. According to the present invention, the intermediate product is basically solid and is easily crystallized and purified; and the method has characteristics of high yield, low production cost and easy operation, and is suitable for industrial production. Thecompounds 1, 2, 3 and 4 are defined in the specification.
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Paragraph 0083-0084; 0086
(2018/09/11)
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- Synthesis and Characterization of Urofuranoic Acids: In Vivo Metabolism of 2-(2-Carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic Acid (CMPF) and Effects on in Vitro Insulin Secretion
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CMPF (2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid) is a metabolite that circulates at high concentrations in type 2 and gestational diabetes patients. Further, human clinical studies suggest it might have a causal role in these diseases. CMPF inhibits insulin secretion in mouse and human islets in vitro and in vivo in rodents. However, the metabolic fate of CMPF and the relationship of structure to effects on insulin secretion have not been significantly studied. The syntheses of CMPF and analogues are described. These include isotopically labeled molecules. Study of these materials in vivo has led to the first observation of a metabolite of CMPF. In addition, a wide range of CMPF analogues have been prepared and characterized in insulin secretion assays using both mouse and human islets. Several molecules that influence insulin secretion in vitro were identified. The molecules described should serve as interesting probes to further study the biology of CMPF.
- Nagy, Edith,Liu, Ying,Prentice, Kacey J.,Sloop, Kyle W.,Sanders, Phillip E.,Batchuluun, Battsetseg,Hammond, Craig D.,Wheeler, Michael B.,Durham, Timothy B.
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p. 1860 - 1875
(2017/03/17)
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- METHOD FOR PRODUCING EPSILON-CAPROLACTAM
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A method for selective production of ε-caprolactam, wherein a substance inducible from a biomass resource is used as a material; the reaction process is short; ammonium sulfate is not produced as a by-product; and production of by-products is suppressed; is disclosed. The method for producing ε-caprolactam comprises the step of reacting a particular compound inducible from a biomass resource, such as α-hydromuconic acid, 3-hydroxyadipic acid, or 3-hydroxyadipic acid-3,6-lactone, or a salt thereof with hydrogen or ammonia.
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Paragraph 0048; 0049; 0052; 0053; 0056; 0057
(2017/11/29)
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- Convenient syntheses of δ-aminolevulinic acid
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Two convenient procedures for the synthesis of δ-aminolevulinic acid (5-ALA) are described.
- Nudelman, Ayelet,Nudelman, Abraham
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p. 568 - 570
(2007/10/03)
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- SYNTHESIS OF DIMETHYL β-OXOADIPATE
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Acetoacrtic ester and Meldrum's acid provide a new and simple synthesis of dimethyl β-oxoadipate.This compounds is a synthone for some natural and biologically active compounds.
- Zav'yalev, S. I.,Zavozin, A. G.,Kravchenko, N. E.
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p. 1104 - 1106
(2007/10/02)
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- REMOTE SUBSTITUENT EFFECTS IN MICROBIAL REDUCTIONS OF 3-KETOGLUTARATE AND 3-KETOADIPATE ESTERS
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The enantioselectivity of yeast mediated reductions of prochiral 3-ketoglutarate and 3-ketoadipate esters to the corresponding 3-hydroxyesters can be influenced by simple differences in the ester groups.
- Brooks, Dee W.,Lee, Nola Castro de,Peevey, Richard
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p. 4623 - 4626
(2007/10/02)
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- Meerwein Saponification of Alkyl 3-Oxoalkanoates in the Gas Chromatograph
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Alkyl 3-oxoalkanoates decompose by unevitable traces of water in the gas chromatograph to yield the corresponding methyl ketones and alcohols (Meerwein saponification).Decomposition occurs in the hot injector (T= 270 deg C) of the gas chromatograph and also on glass capillary columns (T> 160 deg C).Decomposition in routine work can be avoided by preparing the corresponding 3-trimethylsilyl enol ethers.
- Thoma, Heinz,Spiteller, Gerhard
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p. 1237 - 1248
(2007/10/02)
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