Immobilised Candida antarctica B as efficient catalyst for the synthesis of local anaesthetic intermediates
We hereby present the development of new reaction conditions for the CALB catalysed esterification of substituted benzoic acids. Using cyclohexane as the reaction media a number of heptyl benzoates have been easily isolated in good to excellent yields (up to 100% at 80 C, 20-24 h). Moreover, the catalytic system has been successfully applied to the synthesis of local anaesthetics intermediates also showing good productivity in recycling experiments.
Giunta, Daniela,Masia, Maria Paola,Marchetti, Mauro,Morrone, Raffaele,Solinas, Maurizio
supporting information
p. 5122 - 5125
(2013/08/28)
Esterification Using a Polymer-Supported Phosphine Reagent
-
Amos, Richard A.,Emblidge, Robert W.,Havens, Nick
p. 3598 - 3600
(2007/10/02)
More Articles about upstream products of 5462-02-2