Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)
A series of unique bicyclic aminooxazolines were synthesized and found to exhibit micromolar inhibition of β-secretase-1 (BACE-1). The aminooxazolines were procured by an intramolecular diethylaminosulfur trifluoride (DAST)-mediated ring closure of a benz
Huestis, Malcolm P.,Liu, Wendy,Volgraf, Matthew,Purkey, Hans E.,Yu, Christine,Wang, Weiru,Smith, Darin,Vigers, Guy,Dutcher, Darrin,Hunt, Kevin W.,Siu, Michael
p. 5802 - 5807
(2013/10/01)
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