- Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo
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Background: Hemithioindigo is a promising molecular photoswitch that has only recently been applied as a photoswitchable pharmacophore for control over bioactivity in cellulo. Uniquely, in contrast to other photoswitches that have been applied to biology,
- Ahlfeld, Julia,Bingham, Rebekkah,Ermer, Franziska,Kraus, Yvonne,Lutter, Ferdinand H.,Sailer, Alexander,Thorn-Seshold, Oliver
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supporting information
p. 125 - 134
(2020/03/27)
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- In situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes
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An environmentally friendly synthetic route by the application of CO2 to synthesize amides via in situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes was developed. Various secondary and tertiary amides have been synthesized in moderate to good yields under mild and neutral reaction conditions. The use of amine hydrochloride salts and hence base for neutralization step is totally avoided in this protocol.
- Bathini, Thulasiram,Rawat, Vikas S.,Bojja, Sreedhar
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supporting information
p. 5656 - 5660
(2015/09/15)
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- Magnetic CuFe2O4nanoparticles: A retrievable catalyst for oxidative amidation of aldehydes with amine hydrochloride salts
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The application of magnetic CuFe2O4nanoparticles for the oxidative amidation of aldehydes with amine hydrochloride salts is described. A wide range of amides have been synthesized in good to excellent yields under mild conditions. Chiral amide also synthesized from its corresponding chiral amine salt with retention of the stereochemistry. In particular, the performance of the magnetic separation of the catalyst was very efficient and an alternative to time, solvent and energy-consuming separation procedures. The catalytic activity of the catalyst remains unaltered after five consecutive cycles, making it environmentally benign and widely applicable due to its efficiency, ease of handling and cost effectiveness.
- Suresh Kumar,Thulasiram,Bala Laxmi,Rawat, Vikas S.,Sreedhar
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supporting information
p. 6059 - 6067
(2014/12/10)
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- Magnetic CuFe2O4 nanoparticles: A retrievable catalyst for oxidative amidation of aldehydes with amine hydrochloride salts
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The application of magnetic CuFe2O4 nanoparticles for the oxidative amidation of aldehydes with amine hydrochloride salts is described. A wide range of amides have been synthesized in good to excellent yields under mild conditions. Chiral amide also synthesized from its corresponding chiral amine salt with retention of the stereochemistry. In particular, the performance of the magnetic separation of the catalyst was very efficient and an alternative to time, solvent and energy-consuming separation procedures. The catalytic activity of the catalyst remains unaltered after five consecutive cycles, making it environmentally benign and widely applicable due to its efficiency, ease of handling and cost effectiveness.
- Suresh Kumar,Thulasiram,Bala Laxmi,Rawat, Vikas S.,Sreedhar
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supporting information
p. 6059 - 6067
(2015/03/30)
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- A palladium-catalyzed ullmann-ziegler cross-coupling for sterically hindered biaryls
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We present a facile and versatile biaryl cross-coupling procedure based on a modified Ullmann coupling that may be applied to a wide range of substrates. This even allows the coupling of sterically hindered substrates under mild reaction conditions. Georg
- Nuellen, Max P.,Goettlich, Richard
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experimental part
p. 1249 - 1254
(2011/05/14)
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- A mixed naphthyl-phenyl phosphine ligand motif for Suzuki, Heck, and hydrodehalogenation reactions
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Nap-Phos, representing a new naphthyl-phenyl biaryl-type phosphine ligand class and available by a short synthesis (4 steps, 71% overall yield), effectively catalyzes the Suzuki-Miyaura (including highly hindered cases), hydrodehalogenation, and Heck reactions. Georg Thieme Verlag Stuttgart.
- Demchuk, Oleg M.,Yoruk, Bilge,Blackburn, Tom,Snieckus, Victor
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p. 2908 - 2913
(2008/02/12)
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- Synthetic racemate and enantiomers of cytosporone E, a metabolite of an endophytic fungus, show indistinguishably weak antimicrobial activity
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The racemate and the enantiomers of cytosporone E [3-heptyl-4,5,6- trihydroxyphthalide (1)], a metabolite of the endophytic fungus, CR200 (Cytospora sp.), were synthesized. The key steps were (i) Sharpless asymmetric dihydroxylation of an alkene (8) and (
- Ohzeki, Tomoya,Mori, Kenji
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p. 2584 - 2590
(2007/10/03)
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- A direct and mild conversion of tertiary aryl amides to methyl esters using trimethyloxonium tetrafluoroborate: A very useful complement to directed metalation reactions
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The scope and generality of a direct process for the conversion of tertiary amides directly to methyl esters has been investigated. The process involves a two-step, one pot procedure in which a tertiary amide is first treated with trimethyloxonium tetrafluoroborate to generate an imidate intermediate which is then hydrolyzed, generally by the addition of saturated aqueous sodium bicarbonate solution. Although this process fails for aliphatic amides, very good yields are realized for a variety of amides derived from aromatic carboxylic acids. Steric hindrance at the N-alkyl group is well tolerated; thus N,N-dimethyl, -diethyl, and -diisopropyl amides can all be utilized successfully. (C) 2000 Elsevier Science Ltd.
- Keck, Gary E,McLaws, Mark D,Wager, Travis T
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p. 9875 - 9883
(2007/10/03)
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- Stereochemical variations on the colchicine motif. Part 4. A remote metalation approach toward a colchicine analog with a five-membered B-ring.
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Attempts to prepare a colchicine analog with a 5-membered B-ring by remote metalation of N,N-diethyl-3,4,5-trimethoxy-2-(5'-methoxy-4'-oxo-2', 5',7'-cycloheptatrienyl)-benzamide (2) led to ring contraction of the methoxytropone ring to the p-methoxycarbonylphenyl derivative (3). Dynamic 1H NMR investigations showed that the biaryl amide 2 exists as a mixture of diastereomers due to hindered rotation around both aryl-aryl and aryl-amide bonds, with rotational barriers of ca. 63 kJ mol-1. The colchicine and allocolchicine analogs 2 and 3 do not notably affect tubulin polymerization, despite the structural similarities with active analogs. The reduced tubulin binding activity of 2 and 3 may be a result of increasing steric bulk.
- Berg,Bladh
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p. 1380 - 1385
(2007/10/03)
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