P38 MAP kinase inhibitors. part 1: Design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold
A new class of p38 antagonists based on 3,4-dihydropyrido[3,2,-d]pyrimidine scaffold has been developed. These inhibitors exhibit unprecedented selectivity towards p38 over other very closely related kinases. Compounds 25, 33, and 34 were identified as be
Natarajan, Swaminathan R.,Wisnoski, David D.,Singh, Suresh B.,Stelmach, John E.,O'Neill, Edward A.,Schwartz, Cheryl D.,Thompson, Chris M.,Fitzgerald, Catherine E.,O'Keefe, Stephen J.,Kumar, Sanjeev,Hop, Cornelis E. C. A.,Zaller, Dennis M.,Schmatz, Dennis M.,Doherty, James B.
p. 273 - 276
(2014/12/12)
SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors
Development for a class of potent 3,4-dihydropyrido(3,2-d)pyrimidone inhibitors of p38a MAP kinase is described. Modification of N-1 aryl and C-6 arylsulfide in 3,4-dihydropyrido(3,2-d)pyrimidone analogues for the interaction with the hydrophobic pockets
Liu, Luping,Stelmach, John E.,Natarajan, Swaminathan R.,Chen, Meng-Hsin,Singh, Suresh B.,Schwartz, Cheryl D.,Fitzgerald, Catherine E.,O'Keefe, Stephen J.,Zaller, Dennis M.,Schmatz, Dennis M.,Doherty, James B.
p. 3979 - 3982
(2007/10/03)
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