54788-43-1

Basic information

• Product Name: alaphosphin
• Synonyms: (1-((2-Amino-1-oxopropyl)amino)ethyl)phosphonic acid;N-D-Alanyl-1-aminoethylphosphonic acid;Phosphonic acid, (1-((2-amino-1-oxopropyl)amino)ethyl)-
• CAS NO: 54788-43-1
• Molecular Formula: C₅H₁₃N₂O₄P
• Molecular Weight: 196.142
• Mol File: 54788-43-1.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.395g/cm³
• Refractive Index: 1.512
• CAS DataBase Reference: alaphosphin(CAS DataBase Reference)
• NIST Chemistry Reference: alaphosphin(54788-43-1)
• EPA Substance Registry System: alaphosphin(54788-43-1)

Safety Data

• Hazardous Substances Data: 54788-43-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H13N2O4P/c1-3(6)5(8)7-4(2)12(9,10)11/h3-4H,6H2,1-2H3,(H,7,8)(H2,9,10,11)

Upstream product

• 54788-36-2 diethyl N-benzyloxycarbonyl-D-alanyl-1-aminoethylphosphonate 
• 126306-90-9 [1-((S)-2-Benzyloxycarbonylamino-propionylamino)-ethyl]-phosphonic acid diisopropyl ester 

Relevant articles and documents

STEREOSELECTIVE PAPAIN-CATALYZED SYNTHESIS OF ALAFOSFALIN

Papain in powdered form efficiently catalyzes alafosfalin synthesis in miscible aqueous-organic solvent involving L-aminophosphonate in peptide bond formation.

STUDIES ON THE SYNTHESIS OF CHEMOTHERAPEUTICS. PART XI. SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF PHOSPHONOPEPTIDES

A variety of phosphonopeptides, shown in 2 as a general formula, containg natural and/or unnatural amino acids were synthesized, and their in vitro antibacterial activities were examined.N-Protected amino acids were condensed with 1-amino-ethylphosphonic acid or its ester followed by deprotection and hydrolysis to give the requisite phosphonopeptides.Several compounds showed higher levels of activity against certain members of Gram-negative bacteria than those of Alafosfalin (1) as the standard phosphonopeptide.A brief discussion on structure-activity relationships is also described.