548454-47-3

Basic information

• Product Name: 2-methoxy-N-{3-[(2-methoxybenzoyl)amino]phenyl}benzamide
• Synonyms: 2-methoxy-N-{3-[(2-methoxybenzoyl)amino]phenyl}benzamide
• CAS NO: 548454-47-3
• Molecular Formula: C₂₂H₂₀N₂O₄
• Molecular Weight: 376.4052
• Mol File: 548454-47-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-methoxy-N-{3-[(2-methoxybenzoyl)amino]phenyl}benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-N-{3-[(2-methoxybenzoyl)amino]phenyl}benzamide(548454-47-3)
• EPA Substance Registry System: 2-methoxy-N-{3-[(2-methoxybenzoyl)amino]phenyl}benzamide(548454-47-3)

Safety Data

• Hazardous Substances Data: 548454-47-3(Hazardous Substances Data)

Upstream product

• 96748-34-4 2-methoxy-benzoic acid-(3-nitro-anilide) 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 99-09-2 3-nitro-aniline 
• 301207-46-5 N-(3-amino-phenyl)-2-methoxy-benzamide 

Relevant articles and documents

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors that avoid the closely related TASK-3 channel has been challenging. In this study, a series of bis-amide derived compounds were found to demonstrate improved TASK-1 selectivity over TASK-3 compared to reported inhibitors. Optimization of a marginally selective hit led to analog 35 which displays a TASK-1 IC 50 = 16 nM with 62-fold selectivity over TASK-3 in an orthogonal electrophysiology assay.