- Facile preparation of conjugated dienes from allylic alcohols
-
An efficient two-step procedure to prepare conjugated dienes from allylic alcohols is developed without the formation of regioisomers and rearranged products.
- Kitahara,Matsuoka,Kiyota,Warita,Kurata,Horiguchi,Mori
-
-
Read Online
- Stereoselective and Modular Assembly Method for Heterocycle-Fused Daucane Sesquiterpenoids
-
A stereoselective synthetic method is reported for the molecular framework found in common daucane and isodaucane sesquiterpenoid natural products. The synthetic method constitutes a scalable, modular, and also asymmetric access to a complex natural product scaffold, wherein the substitution pattern and the stereochemistry can be adjusted simply by choosing different starting materials. The method allows the rapid introduction of diverse heterocyclic substructures such as (benzo)furans, (benzo)thiophenes, dithiins, thiazoles, and indoles, which actually also facilitate and direct the key intramolecular annulation step.
- Christiaens, Mien,Hullaert, Jan,Van Hecke, Kristof,Laplace, Duchan,Winne, Johan M.
-
p. 13783 - 13787
(2018/09/06)
-
- Preparation method of solanone and synthetic intermediate thereof
-
The invention relates to a preparation method of solanone and a synthetic intermediate thereof and provides a safe industrial method using not many steps to prepare a large amount of solanone as a flavor compound. The solution comprises using N-(3-methyl-1-yl) piperidine and 4-acryloyl morpholine for Michael addition reaction , then performing hydrolysis of acid to generate a novel aldehyde, making the aldehyde to carry out Wittig reactions, so that a novel morpholine amide compound is provided as a synthetic intermediate of the preparation method of the solanone. Then the compound reacts with a Grignard reagent, so that the solanone is prepared by means of the industrial method.
- -
-
-
- TERPENOIDS. SYNTHESIS OF (PLUS OR MINUS)-U- CADINENE
-
The starting compound 2-isopropyl- 4- carbethoxybutanal when subjected to Wittig reaction with methallylidenetriphenylphosphorane affords 2-methyl- 5- isopropyl - 7 - carbethoxy- 1,3 - heptadiene. The resulting product on Diels-Alder reaction with ethyl acrylate yields 1-methyl- 4- carbethoxy - 3 - (1 - isopropyl - 3 - carbethoxy -n - propyl) - cyclohex- lene. Cyclization of the diester followed by hydrolysis and decarboxylation gives 2-methyl- 5-oxo- 8- isopropyl - delta- l - decalene which on Wittig reaction with methylenetriphenylphosphorane furnishes (plus or minus)-U- cadinene.
- VIG OP,CHUGH OP,MATTA KL
-
-