Exploitation of a tuned oxidation with N -haloimides in the synthesis of caulibugulones A-D
Marine alkaloids caulibugulones A-D were synthesized in six steps starting from the readily available 2,5-dimethoxybenzaldehyde. Pomeranz-Fritsch reaction of N-(2,5-dimethoxybenzyl)-N-(2,2-dimethoxyethyl)-2-nitrobenzenesulfonamide proceeded smoothly to gi
Naciuk, Fabrício F.,Milan, Julio C.,Andre?o, Almir,Miranda, Paulo C.M.L.
p. 5026 - 5030
(2013/07/11)
Synthesis of Indenoisoquinoliniums and Methods of Use
Substituted indenoisoquinolinium compounds, and pharmaceutical formulations of substituted indenoisoquinolinium compounds are described. Also described are processes for preparing substituted indenoisoquinolinium compounds. Also described are methods for
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(2008/12/07)
Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis
Several norindenoisoquinolines substituted with methoxy or methylenedioxy groups have been prepared and their anticancer properties evaluated in cancer cell cultures and in topoisomerase I inhibition assays. 2,3-Dimethoxy-8,9- methylenedioxy-11H-indeno[1,
Ioanoviciu, Alexandra,Antony, Smitha,Pommier, Yves,Staker, Bart L.,Stewart, Lance,Cushman, Mark
p. 4803 - 4814
(2007/10/03)
Total chemical synthesis and antitumor evaluation of the 9-Aza analogue of N-(trifluoroacetyl)-4-demethoxydaunomycin
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Mitscher,Gill,Filppi,Wolgemuth
p. 1277 - 1281
(2007/10/02)
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