- Synthesis of 3-chloro-4-fluorophenyl-3,4-dichlorophenyl substituted thiocarbamide derivatives as potential antitubercular agents
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A series of dihalosubstituted thiocarbamide derivatives (5a-e, 6a-e, 7a-e, and 8a-e) were synthesized as antitubercular agents. The structures of dihalosubstituted thiocarbamide derivatives were established on the basis of IR, 1H, 13C NMR, and mass spectral data. All the compounds were tested in vitro for antimycobacterial activity against Mycobacterium tuberculosis (ATCC-25177) by well-diffusion method and MIC by serial dilution method. Results of the antitubercular screening revealed that some of the compounds showed moderate to good antitubercular activity. Of all the compounds tested, two derivatives viz., 8d and 8e expressed MIC of 25 μg/ml, and one compound 7e showed MIC of 12.5 μg/ml against M. tuberculosis (ATCC-25177). Graphical Abstract: [Figure not available: see fulltext.]
- Faiz Arshad,Kumar, Suresh,Al Rohaimi, Abdulmohsen H.,Hassan, Allam A.,Elkerdasy, Ahmed,Upmanyu, Neeraj
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p. 334 - 343
(2015/03/18)
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- AMINOMETHYL-2-IMIDAZOLES
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The present invention relates to compounds of formula I wherein R1 is selected from the group consisting of hydrogen or lower alkyl; R2 is hydrogen, lower alkyl, lower alkenyl, lower alkyl substituted by hydroxy, lower alkyl substitu
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Page/Page column 22
(2008/06/13)
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- A novel and efficient approach to mono-N-alkyl anilines via addition of Grignard reagents to aryl azides
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Mono-N-alkyl anilines were obtained in high yields within a short reaction time when various aromatic azides were reacted with alkyl magnesium halides at room temperature.
- Sampath Kumar,Subba Reddy,Anjaneyulu,Yadav
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p. 8305 - 8306
(2007/10/03)
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