- Preparation method of naphazoline hydrochloride
-
The invention relates to the technical field of organic synthesis, in particular to a preparation method of naphazoline hydrochloride, which comprises the following steps: by using alpha-naphthylacetic acid, ethylenediamine and acetone as raw materials, carrying out condensation, cyclization, salification and the like to prepare 4, 5-dihydro-2-(1-naphthyl methyl)-1H-imidazole hydrochloride. Alpha-naphthylacetic acid, ethylenediamine and acetone are used as raw materials to prepare the target product, and the raw materials are easy to obtain and low in price. Condensation, cyclization and salification are adopted, the operation reaction conditions are mild, a large number of side reactions are avoided, and the high yield is obtained. The preparation process is high in coherence, short in time consumption and more efficient and thorough in reaction. The preparation process is simple, reaction conditions are mild, and environmental pollution is avoided.
- -
-
Paragraph 0015-0022
(2021/01/24)
-
- Preparation method of naphazoline hydrochloride
-
The invention discloses a preparation method of naphazoline hydrochloride. A specific sulfur-containing catalyst CS2, Na2S or thiourea is used for synthesizing naphazoline, and a naphazoline hydrochloride product with high yield, high purity and good powder property is obtained through simple salification and recrystallization processes.
- -
-
Paragraph 0040; 0043-0044; 0045; 0048-0049; 0050; 0053-0054
(2019/08/03)
-
