- From alkenes to alcohols by cobalt-catalyzed hydroformylation-reduction
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The cobalt-catalyzed hydroformylation of alkenes in the presence of a range of novel cyclic phosphine ligands was investigated. The effect of various parameters such as solvents, additives, cobalt/phosphine ratio, CO/H2 (1:2), and nature of the alkenes was examined. The results revealed that both terminal and internal alkenes are hydroformylated in high yields to give mainly linear products at moderate temperature and syn gas pressure. The linearity ranges from 43 to 85%, with Lim-10 giving the highest proportion of linear product.
- Achonduh, George,Yang, Qian,Alper, Howard
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supporting information
p. 1241 - 1246
(2015/03/05)
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- Ophthalmic compositions containing a nitric oxide donor
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The present invention relates to compositions comprising a 4-nitrooxybutan-1-ol alkyl ester as nitric oxide donor. More specifically, the invention relates to compositions comprising 4-nitrooxybutan - 1-ol alkyl ester as a nitric oxide donor and an ophthalmic drug, useful in controlling elevated intraocular pressure associated with glaucoma or ocular hypertension associated with other diseases or conditions. The invention is also directed to methods of controlling intraocular pressure utilizing said compositions.
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Paragraph 0066
(2015/02/02)
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- OPHTHALMIC COMPOSITIONS CONTAINING A NITRIC OXIDE DONOR
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The present invention relates to compositions comprising a 4-nitrooxybutan-1-ol alkyl ester as nitric oxide donor. More specifically, the invention relates to compositions comprising 4-nitrooxybutan-1-ol alkyl ester as a nitric oxide donor and an ophthalmic drug, useful in controlling elevated intraocular pressure associated with glaucoma or ocular hypertension associated with other diseases or conditions. The invention is also directed to methods of controlling intraocular pressure utilizing said compositions.
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Page/Page column 14
(2015/02/02)
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- Synthesis and biological evaluation of novel AM80 derivatives as antileukemic agents
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A series of novel AM80 derivatives as antileukemic agents were synthesized and their structures were confirmed by IR, 1H-NMR, and HR-MS spectra. All the target compounds were evaluated for in vitro antiproliferative activities against human leukemic HL-60, NB4, and K562 cell lines. Among these derivatives, compound 4g showed much stronger antiproliferative activities against all the three human leukemic cell lines than the positive control AM80, and compound 4b exhibited more active antiproliferative effects against HL-60 and K562 cells than AM80. Furthermore, the preliminary SAR analysis suggested that AM80 conjugating with HDAC inhibitors with small steric hindrance could give more effective antileukemic agents. These results would be helpful to design more potent antileukemic drugs for the treatment of human leukemia.
- Bian, Haiyong,Feng, Jinhong,Xu, Wenfang
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p. 175 - 185
(2013/03/13)
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- Rational engineering of Candida antarctica lipase B for selective monoacylation of diols
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The enzyme Candida antarctica lipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations. This journal is The Royal Society of Chemistry 2012.
- Hamberg, Anders,Maurer, Steffen,Hult, Karl
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supporting information
p. 10013 - 10015
(2012/10/30)
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- PROCESS FOR PREPARING 1,4-BUTANDIOL MONONITRATE
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The present invention relates to a process for the preparation of 1,4-butanediol mononitrate as intermediate for large scale preparation of high purity nitrooxybutyl ester of pharmaceutically active compounds.
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Page/Page column 22
(2009/03/07)
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- Synthesis of symmetrical and unsymmetrical 1,2-Diketones through cathodic intramolecular coupling of diesters
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Electroreduction of diesters [R1COO(CH2)2OCOR2] with Mg electrode has been found to give the corresponding unsymmetrical 1,2-Diketones (R1COCOR2) with excellent yields.
- Kashimura, Shigenori,Murai, Yoshihiro,Washika, Chise,Yoshihara, Daisuke,Kataoka, Yasuki,Murase, Hiroaki,Shono, Tatsuya
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p. 6717 - 6720
(2007/10/03)
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