- Rhodium-Catalyzed C?H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N-Oxides
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A β-hydroxy elimination instead of common oxidization to carbonyl group in secondary propargyl alcohols was successfully developed to form 2-benzyl substituted isoquinoline N-oxides by a Rhodium-catalyzed C?H activation and annulation cascade, in which moderate to excellent yields (up to 92%) could be obtained under mild reaction conditions, along with good regioselectivity, broad generality and applicability. (Figure presented.).
- Li, Yuan,Fang, Feifei,Zhou, Jianhui,Li, Jiyuan,Wang, Run,Liu, Hong,Zhou, Yu
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supporting information
p. 3305 - 3310
(2021/05/17)
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- Regioselective Rh-Catalyzed Hydroformylation of 1,1,3-Trisubstituted Allenes Using BisDiazaPhos Ligand
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The efficient hydroformylation of 1,1,3-trisubstituted allenes is accomplished with low loadings of a Rh catalyst supported by a BisDiazaPhos (BDP) ligand. The ligand identity is key to achieving high regioselectivity, while the mild reaction conditions m
- Eshon, Josephine,Landis, Clark R.,Schomaker, Jennifer M.
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p. 9270 - 9278
(2017/09/22)
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- Metal-Free CH-CH-Type Cross-Coupling of Arenes and Alkynes Directed by a Multifunctional Sulfoxide Group
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A metal-free CH-CH-type coupling of arenes and alkynes, mediated by a multifunctional sulfoxide directing group, exploits nonprefunctionalized coupling partners, proceeds under mild conditions, is operationally simple, and exhibits high functional group t
- Fernández-Salas, José A.,Eberhart, Andrew J.,Procter, David J.
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supporting information
p. 790 - 793
(2016/02/05)
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- Gold-catalyzed isomerization of unactivated allenes into 1,3-dienes under ambient conditions
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We have developed a gold-catalyzed isomerization of unactivated allenes into 1,3-dienes with nitrosobenzene as an additive. This reaction proceeded almost exclusively at room temperature for highly substituted allenes. The utility of this reaction is manifested by the development of one-pot [4+2]-cycloaddition of allenes and reactive alkenes.
- Ting, Chun-Ming,Hsu, Yi-Ling,Liu, Rai-Shung
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supporting information; experimental part
p. 6577 - 6579
(2012/07/31)
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- S1P RECEPTORS MODULATORS AND THEIR USE THEREOF
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The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as autoimmune response.
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Page/Page column 77
(2010/04/30)
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- Diastereoselectivity in the [2,3]-sigmatropic rearrangement of substituted allylic N,N-dialkylamidosulfoxylates. X-ray molecular structure of [(1′) S*, (S)S*]-(2′E)-4-[[3′-(4″-bromophenyl)-1′-methyl- 2′-propenyl]sulfinyl]-morpholine
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By the reaction with three N,N-dialkylamidosulfenyl chlorides 2 bearing representative sizes for the R groups on the nitrogen atom, several substituted secondary E or Z allylic alcohols (1a-h) have been converted into the corresponding pairs of diastereoisomeric allylic sulfinamides (3+-3′a-v), whose ratios have been determined by 1H NMR spectroscopy. Five cases of entirely diastereoselective [2,3]-sigmatropic rearrangement have been observed. The stereochemistry of one pure diastereoisomer 3′m has been determined by single crystal X-Ray analysis. When treated with 4-morpholinesulfenyl chloride, cyclohex-2-en-1-ol is stereoselectively converted to one diastereoisomer of the sulfinamide 5b which, by unambiguous procedures, led to the sane p.tolylsulfoxide 5a already obtained by treatment of cyclohex-2-en-1-ol with toluene-p-sulfenyl chloride.
- Baudin, Jean-Bernard,Bkouche-Waksman, Itka,Hareau, Georges,Julia, Sylvestre A.,Lorne, Robert,Pascard, Claudine
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p. 6655 - 6672
(2007/10/02)
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