A New and Improved Synthesis of 6-Aryl-1,2,4-triazolopyridazines
A new and improved synthesis of 6-aryl-1,2,4-triazolopyridazines is described.This methodology provides the title compounds under mild conditions and in high yields.The first step comprises the condensation of an aryl methyl ketone with a 4-amino-1
Lieberman, Daniel F.,Albright, J. Donald
p. 827 - 830
(2007/10/02)
Synthesis and Anxiolytic Activity of 6-(Substituted-phenyl)-1,2,4-triazolopyridazines
The synthesis of a series of 6-(substituted-phenyl)-1,2,4-triazolopyridazines (VIII) is reported.Some of these derivatives show activity in tests predictive of anxiolytic activity (a) protection against pentylenetetrazole-induced convulsions; (b)
Albright, J. D.,Moran, D. B.,Wright, W. B.,Collins, J. B.,Beer, B.,et al.
p. 592 - 600
(2007/10/02)
6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as anxiolytic agents.
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(2008/06/13)
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