550998-27-1

Basic information

• Product Name: 1-CHLORO-7-METHOXYNAPHTHALENE
• Synonyms: 1-CHLORO-7-METHOXYNAPHTHALENE;Naphthalene, 1-chloro-7-Methoxy-
• CAS NO: 550998-27-1
• Molecular Formula: C₁₁H₉ClO
• Molecular Weight: 192.64
• Mol File: 550998-27-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-CHLORO-7-METHOXYNAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-7-METHOXYNAPHTHALENE(550998-27-1)
• EPA Substance Registry System: 1-CHLORO-7-METHOXYNAPHTHALENE(550998-27-1)

Safety Data

• Hazardous Substances Data: 550998-27-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Chloro-7-methoxynaphthalene is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
1-CHLORO-7-METHOXYNAPHTHALENE is also utilized as a building block in the synthesis of agrochemicals, playing a role in the creation of pesticides and other agricultural products to enhance crop protection and yield.
Used in Dye Production:
1-Chloro-7-methoxynaphthalene is used as an intermediate in the production of dyes, contributing to the development of colorants for various applications, including textiles, plastics, and printing inks.
Used in Organic Compound Synthesis:
As an intermediate, 1-chloro-7-methoxynaphthalene is employed in the synthesis of other organic compounds, expanding its applications across different industries that rely on organic chemistry for product development.

Upstream product

• 99861-03-7 4-(2,4,4,4-tetrachloro-butyl)-anisole 
• 5302-79-4 7-methoxynaphthalen-1-amine 
• 118-46-7 8-amino-2-naphthol 
• 93189-18-5 N-(7-methoxynaphthalen-1-yl)acetamide 
• 140-67-0 Estragole 
• 540-80-7 tert.-butylnitrite 
• 6470-18-4 1-acetylamino-7-naphthol 

Downstream Products

• 29921-50-4 8-chloronaphthalen-2-ol 
• 550998-34-0 tert-butyl[(3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthyl)oxy]dimethylsilane 
• 550998-46-4 3-bromo-1,8-dichloro-6-(4-methoxyphenyl)-2-naphthol 
• 550998-48-6 1,8-dichloro-6-(4-methoxyphenyl)-2-naphthol 
• 550998-37-3 3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthol 
• 550998-42-0 8-chloro-6-(4-methoxyphenyl)-2-naphthol 

Relevant articles and documents

A Visible Light and Iron-mediated Carbocationic Route to Polysubstituted 1-Halonaphthalenes by Benzannulation using Allylbenzenes and Polyhalomethanes

A wide array of polysubstituted 1-bromo and chloronaphthalenes are obtained from coupling of allylbenzenes and polyhalomethanes. The reaction is mediated by iron metal under visible light irradiation and proceeds via a Kharasch addition intermediate followed by intramolecular FeIII mediated Friedel-Crafts alkylation, with the formation of two Csp2?Csp2 bonds in the process. This method gives easy access to 1-halonaphthalenes with substituent(s) at C-5 to C-8 that are otherwise hard to synthesize. (Figure presented.).

ERβ ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERβ selectivity

The 2-phenylnaphthalene scaffold was explored as a simplified version of genistein in order to identify ER selective ligands. With the aid of docking studies, positions 1, 4, and 8 of the 2-phenylnaphthalene template were predicted to be the most potentially influential positions to enhance ER selectivity using two different binding orientations. Both orientations have the phenol moiety mimicking the A-ring of genistein. Several compounds predicted to adopt orientations similar to that of genistein when bound to ERβ were observed to have slightly higher ER affinity and selectivity than genistein. The second orientation we exploited, which was different from that of genistein when bound to ERβ, resulted in the discovery of several compounds that had superior ER selectivity and affinity versus genistein. X-ray structures of two ER selective compounds (i.e., 15 and 47) confirmed the alternate binding mode and suggested that substituents at positions 1 and 8 were responsible for inducing selectivity. One compound (i.e., 47, WAY-202196) was further examined and found to be effective in two models of inflammation, suggesting that targeting ER may be therapeutically useful in treating certain chronic inflammatory diseases.

Substituted phenyl naphthalenes as estrogenic agents

This invention provides estrogen receptor modulators of formula I, having the structure 1wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.