55131-09-4Relevant articles and documents
Metasubstituted thiazolidinones, their manufacture and use as a drug
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Page/Page column 43-44, (2010/11/25)
This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.
Photochemical smiles rearrangement and meisenheimer complex formation catalyzed by hydroxide ion via electron hole transfer catalysis
Wubbels, Gene G.,Ota, Nobutoshi,Crosier, Michelle L.
, p. 4741 - 4744 (2007/10/03)
(Chemical Equation Presented) Photochemical para-to-nitro Smiles rearrangement and para-to-nitro Meisenheimer complex formation occurs for nitrophenoxyethylamines with high concentrations of hydroxide ion in aqueous solution. Both photoreactions show first-order dependence on hydroxide ion concentration, but the mechanism involving hydroxide ion does not involve acid-base catalysis. The reactions take place from the triplet excited states of the nitrophenyl ethers. Analysis of quantum yields and kinetics is consistent with an electron hole transfer catalysis mechanism.
Lewis acids catalyzed ring-opening reactions of methylenecyclopropanes and epoxides in supercritical carbon dioxide or modified supercritical carbon dioxide with perfluorocarbon
Shi, Min,Chen, Yu
, p. 219 - 227 (2007/10/03)
The reactions of methylenecyclopropanes (MCPs) and epoxides with alcohols and aromatic amines can be carried out in supercritical carbon dioxide (scCO2) or modified scCO2 with perfluorocarbon which offer a way to synthesize various alcohols, amino-alcohols, homoallylic ethers, and amines under an environmentally benign condition.
α-Cyclodextrin complexation as a probe of heterolytic general base-catalyzed photo-Smiles rearrangements
Wubbels,Cotter
, p. 6477 - 6480 (2007/10/02)
α-Cyclodextrin complexation of 3-O2NC6H4O(CH2)(n)NH2 inhibits by 40 and 15%, respectively, the efficiency of base-catalyzed and uncatalyzed photo-Smiles rearrangement for n = 2; α-CD complexation inhi
Regioselectivity of Photochemical and Thermal Smiles Rearrangements and Related Reactions of β-(Nitrophenoxy)ethylamines
Wubbels, Gene G.,Halverson, Ann M.,Oxman, Joe D.,Bruyn, Van H. De
, p. 4499 - 4504 (2007/10/02)
The ortho, meta, and para isomers of β-(nitrophenoxy)ethylamine (1, 2, and 3, respectively) have been synthesized as hydrochloride salts.The corresponding ortho, meta, and para isomer of β-(nitrophenoxy)ethyl alcohol (4, 5, or 6, respectively), the Smiles rearrangement product, is formed cleanly in alkaline water by a thermal reaction from 1 or 3 and by a photochemical reaction from the triplet state of 2.Photolysis of 1 or 3 does not cause Smiles rearrangement; photoproducts recovered from 1 and 3 show that β-amino group in both cases bonds at the ring carbon atom adjacent to the side chain and meta to the nitro group.The contrast of these results with those reported for photo-Smiles rearrangements of similar systems containing NHPh as the attacking nucleophile and for intermolecular aromatic photosubstitution by alkylamines is discussed.The results support the recently proposed "energy gap" model for predicting regioseelctivity in heterolytic nucleophilic aromatic photosubstitution.