- DUAL ACTION NITRIC OXIDE DONORS AND THEIR USE AS ANTIMICROBIAL AGENTS
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The present invention relates generally to conjugates comprising a nitric oxide donor and an acyl homoserine lactone, fimbrolide, fimbrolide derivative, dihydropyrrolone or indole, and to the use of such conjugates as antimicrobial agents.
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Page/Page column 75
(2014/05/24)
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- Process for formylation
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Organic basic nitrogen compounds are formylated in the presence of acetic anhydride by adding the nitrogen compound as a salt and carrying out the formylation with an alkali or ammonium formate in an organic solvent having limited miscibility with water.
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- Process for the resolution of D,L-penicillamine and salts formed during said process
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D,L-penicillamine is separated into its antipodes employing optically active threo-1-(p-nitrophenyl)-2-aminopropanediol-1,3.
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- Process for the splitting of the racemate of d-1-phenylpropanolamine
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The d,1-phenylpropanolamine(norephedrine) racemate is split with optically active thiazolidine-4-carboxylic acids of the formula: EQU1 where R1 and R2 are both methyl or are joined together to form the pentamethylene group.
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- Salts of phenylpropanolamine with thiazolidine carboxylic acids
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The d,l-phenylpropanolamine racemate is split with optically active thiazolidine-4-carboxylic acids of the formula: EQU1 where R1 R2 are hydrogen, alkyl of 1 to 8 carbon atoms, cycloalkyl, aryl or alkylene of at least 2 carbon atoms or R1 and R2 together form a ring of alkyl or alkylene with 4 to 12 carbon atoms and AC is acyl, especially benzoyl, tosyl, nitrophenylsulfenyl, acetyl or preferably formyl.
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- Optically active salt of protected D-penicillamine and L-lysine
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D,L-penicillamine is converted to D-penicillamine with the aid of L-lysine.
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