FLUOROGENIC PROBES FOR MEDIUM CHAIN ACYL-COA DEHYDROGENASE ( MCAD )
The present invention relates to compounds useful for detecting the activity of human MCAD, compounds useful for competitively inhibiting human MCAD, as well as methods of manufacture thereof .
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Page/Page column 56
(2008/06/13)
Fluoromorphic substrates for fatty acid metabolism: Highly sensitive probes for mammalian medium-chain acyl-CoA dehydrogenase
(Chemical Equation Presented) Not fussy: A systematic study revealed considerable substrate tolerance of medium-chain acyl-CoA dehydrogenase (MCAD), a member of the β-oxidation pathway for the degradation of fatty acids. Three fluorogenic reporter substra
Froemming, Mary K.,Sames, Dalibor
p. 637 - 642
(2007/10/03)
Niacin receptor agonists, compositions containing such compounds and methods of treatment
The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.