- Dibenzylammonium and Sodium Dibenzyldithiocarbamates as Precipitants for Preconcentration of Trace Elements in Water for Analysis by Energy Dispersive X-ray Fluorescence
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Precipitation with combined dibenzylammonium dibenzyldithiocarbamate and sodium dibenzyldithiocarbamate at pH 5.0 can be used to separate 22 trace elements from water.Membrane filtration of the precipitate yielded a thin sample, suitable for analysis by energy dispersive X-ray fluorescence spectrometry.Alkalis, alkaline earths, lanthanides, and halides were not precipitated, permitting a clean separation of trace elements from the macro constituents of drinking water and drinking water supplies.Methods are given for preparation of reagents of higher purity than previo usly described.
- Moore, Robert V.
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- Photoreduction of 4-nitrophenol to 4-aminophenol Using CdS nanorods
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In this study CdS nanorods (NR), of 46.6 nm average length and diameter ≥3.30 nm (TEM), derived from cadmium(II) dibenzylcarbamodithioate have been used as a visible light driven photocatalyst for the transformation of environmentally detrimental 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) of pharmaceutical significance. As prepared CdS-NR were characterized by powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), selected area electron diffraction technique (SAED), fourier transmission infrared spectroscopy (FTIR), energy dispersive X-ray spectroscopy (EDS), steady-state and time resolved photoluminesce (PL) and UV-visible spectroscopy (band gap of 2.4 eV). PXRD results revealed that CdS-NR exhibit pure hexagonal character. The pho-toluminescence and time-resolved PL have confirmed the low electron–hole recombination rate in CdS-NR than the bulk CdS. The transformation of 4-NP to 4-AP on CdS-NR follows pseudo-first order kinetics with a rate constant 0.202 min?1 and turnover frequency (TOF) 6.06 h?1.
- Nasir, Jamal Abdul,Ambareen, Hina,Khan, Azam,Abdullah Khan,Chen, Wei,Akhter,Zia-Ur-Rehman
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- Dithiocarbamates combined with copper for revitalizing meropenem efficacy against NDM-1-producing Carbapenem-resistant Enterobacteriaceae
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The worldwide prevalence of NDM-1-producing Gram-negative pathogens has drastically undermined the clinical efficacy of carbapenems, prompting a need to devise an effective strategy to preserve their clinical value. Here we constructed a focused compound library of dithiocarbamates and systematically evaluated their potential synergistic antibacterial activities combined with copper. SA09-Cu exhibited excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring meropenem effect, and slowed down the development of carbapenem resistance. Enzymatic kinetic and isothermal titration calorimetry studies demonstrated that SA09-Cu was a noncompetitive NDM-1 inhibitor. The electron paramagnetic resonance (EPR) and X-ray photoelectron spectroscopy (XPS) revealed a novel inhibition mechanism, which is that SA09-Cu could convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme. Importantly, SA09-Cu showed a unique redox tuning ability, and avoided to be reduced by intracellular thiols of bacteria. In vivo experiments indicated that SA09 combined with CuGlu could effectively potentiate MER's effect against NDM-1-producing E. coli (EC23) in the murine infection model. This study provides a highly promising scaffold in developing novel inhibitors to combat NDM-1-producing CREs.
- Chen, Cheng,Yang, Ke-Wu,Zhai, Le,Ding, Huan-Huan,Chigan, Jia-Zhu
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supporting information
(2021/11/20)
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- Synthesis, crystal structure and in vitro anticancer studies of bis(dibenzyldithiocarbamato)Zn(II)
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Bis(dibenzyldithiocarbamato)Zn(II), [Zn(dbzdtc)2], was synthesized and characterized by spectroscopic techniques, elemental analysis and single crystal X-ray crystallography. The compound is crystallized in a monoclinic space group P21/n with Zn(II) located on crystallographic twofold symmetry and coordinated to two molecules of dibenzyl dithiocarbamato anions to form a rare four-coordinate mononuclear Zn(II) complex in a see-saw geometry. The cytotoxicity of the complex was evaluated by MTT assay against breast cancer cells (MCF-7) and human embryonic kidney cells (HEK293). The results showed that the complex is active against MCF-7 breast cancer cells with IC50 value of 6.41 and 4.423?μΜ against HEK293 cell line.
- Ajibade, Peter A.,Sikakane, Berlinda M.,Oluwalana, Abimbola E.,Paca, Athandwe M.,Singh, Moganavelli
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p. 1244 - 1254
(2021/02/26)
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- TRIAZINANE DERIVATIVES AND METHODS OF MAKING THEM
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The present invention is directed to compounds represented by the formula I: wherein R1comprises a hydrogen atom or an alkyl group having 1 to 2 carbon atoms; wherein R2 comprises an alkylene group, an arylene group, or a heterocyclic group; and wherein R3, R4, R5, R6, R7, and R8 are identical or different and comprise a hydrogen atom, an alkyl group, an aryl group, or an alkylaryl group.
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Paragraph 0052
(2021/03/05)
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- Application of dibenzyl dithiocarbamate drug for treating tri-negative breast cancer
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The invention relates to an application of a dibenzyl dithiocarbamate drug for treating three-negative breast cancer. The preparation method comprises the following steps: stirring in an ice water bath, stirring 0.06 μM mass of dibenzylamine and 11.8g of acetonitrile in an ice water bath, adding 150 ml mass of 0.09 μM carbon disulfide 6.96g and 6.96g, suction filtration, and rotary evaporation of the filtrate to obtain a product, and drying the product with diethyl ether to obtain the product 0.09 μM 16 hours. The method comprises the following steps: stirring reaction 13.04g 50% and carrying out suction filtration. The crude product is recrystallized from acetonitrile to obtain dibenzyl dithiocarbamate with a mass of 11.1g. On the basis of the disulfiram anti-cancer structure, the new drug dibenzyldithiocarbamate does not need to be converted in vivo, and the fat solubility is improved.
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Paragraph 0006-0007
(2021/09/29)
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- Method for preparing tetrabenzyl thiuram disulfide
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The invention belongs to the technical field of rubber auxiliary production, and relates to a method for preparing a disulphide tetrabenzyl thiuram disulfide. The method comprises the following steps: sequentially adding water, an aqueous sodium hydroxide solution and dibenzylamine in a reactor, adding a dispersing agent, and then dropwise adding carbon disulfide to perform condensation reaction to obtain the dibenzyldithioformate solution. The sodium dibenzyldithioformate solution is subjected to oxidation reaction and then filtered and dried to obtain a thiurylthiuram disulfide. In the condensation reaction process, the dispersing agent is added, the reaction system forms a uniform state, the reaction process is carried out in a uniform system, two-phase reaction is avoided when carbon disulfide is added dropwise in the prior art, and the reaction effect is poor. COD In the waste water is low, easily waste water treatment. The obtained disulfide tetrabenzylthiuram product has the appearance of white powder and the purity 98% or more.
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Paragraph 0008; 0023; 0027-0028; 0032; 0036; 0040; 0043
(2021/11/21)
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- Synthesis, toxicities and bio-activities of manganese complexes with CO and H2S dual donors
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A series of H2S–CO dual-donors [Mn(CO)4CS2NR1R2] was synthesized, and evaluated from toxicity and bioactivity. The CO–H2S measuring test showed all the complexes not only released CO, but released H2S. The resulting data of cytotoxicity showed all the complexes had activities against the cell proliferation; among them, complexes 1, 2 and 7 displayed higher activities than the others, and their potencies were close to cis-platinum (DDP); whereas the precursors A1-A22 had almost no activities against all five tumor cell lines and W138 cell line proliferation. It is worth noting that complex 1 displayed the highest activity to MCF-7, complex 2 displayed the highest activity to HePG2, and complex 7 showed selectivity inhibition to both A549 and HeLa. The developmental toxicities of the complex were assessed using zebrafish embryos. The results showed complexes 1 and 2 had effect on the mortality and hatching rate of zebrafish embryos in dose-dependent manner. They caused zebrafish malformations when they were over 10 μM. Meanwhile, they displayed dose-dependent toxicities to larval zebrafish. In the test of bio-activities, complexes 1 and 2 had strong anti-inflammatory activities; they not only down-regulated the expression levels of iNOS and TNF-α up-regulated the expression of HO-1 and IL-10, but also up-regulated COX-2 levels. In contrast, the precursor compound (A1 or A2) displayed lower anti-inflammatory activity than the corresponding complex, which suggests both the CO and H2S from the complex took synergistic effects in the process of anti-inflammation. In addition, the complex showed antihypertensive effect and myocardial protection. This effect also possibly resulted from this synergistic effect. All these suggest the complexes have potential to be candidate medicines.
- Bai, Zhongjie,Zhang, Jinlong,Zhang, Qiuping,Zhang, Taofeng,Li, Jili,Zhao, Quanyi,Wang, Zhen,He, Dian,Cheng, Jie,Zhang, Jingke,Liu, Bin
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p. 339 - 356
(2018/10/20)
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- An environment-friendly, high-efficient sulfur cross-linking agent 1,6-bis (N, N-dibenzyl carbamoyl dpds) hexane preparation method (by machine translation)
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The invention relates to an environment-friendly, high-efficient sulfur cross-linking agent 1,6-bis (N, N-dibenzyl carbamoyl dpds) hexane preparation method comprises the steps of: first synthesis of dibenzyl sodium dithiaamino formate, then with 1,6- two hexyl chloride reaction, generating 1,6-bis (N, N-dibenzyl carbamoyl a sulfur) hexane, the composition and sulfur reaction generation product, 1,6-bis (N, N-dibenzyl thio carbamyl dpds) hexane. The product prepared in this invention containing inorganic salt is less, high purity, and the present invention provides method for the preparation of simple and easy, green, generated in the process of preparing the waste water is less, reduce the pollution of the environment. (by machine translation)
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Paragraph 0021; 0029
(2017/01/02)
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- In vitro toxicity of several dithiocarbamates and structure-activity relationships.
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Dithiocarbamates (DTCs) are chemicals featuring a great chelating capacity. The toxicological study of DTCs is very important in view of their relatively simple synthesis and wide array of sanitary and industrial applications. In this study, the toxicity of some of the more recently synthesized DTCs is determined using an extremely simple bioassay, described in previous studies, based on the inhibition of growth of Escherichia coli (IGEC). The lowest-observed-effect concentration (LOEC), the median effective concentration (EC(50)) and no-observed-effect concentration (NOEC) of the following sodium dithiocarbamates was determined: N-benzyl-N-methyldithiocarbamate x 2H(2)O, N-benzyl-N-isopropyldithiocarbamate x 3H(2)O, N-benzyl-N-ethyldithiocarbamate x 2H(2)O, N-butyl-N-methyldithiocarbamate x 2H(2)O, N,N-dibenzyldithiocarbamate x 2H(2)O and N-benzyl-2-phenethyldithiocarbamate x 4H(2)O. Our results showed N,N-dibenzyl-DTC to be the least toxic of the tested substances, with an EC(50) value of 1,269.9 micro g ml(-1), whereas N-butyl-N-methyl-DTC and N-benzyl-N-methyl-DTC, with respective EC(50) values of 14.9 micro g ml(-1) and 23.5 micro g ml(-1), were the most toxic. Regression analysis showed, through exponential models, that the degree of toxicity of this group of substances correlated with the molecular weight of the compound, the molecular weight of the smallest chemical radical linked to the dithiocarbamate group and the number of benzene rings present in the molecule. The consideration of these models allows us to establish that in general terms the toxicity of DTCs decreases exponentially with a greater molecular weight and the number of benzene rings. Copyright 2002 John Wiley & Sons, Ltd.
- Segovia,Crovetto,Lardelli,Espigares
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p. 353 - 357
(2007/10/03)
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- Organyltellurium-(IV) and -(II) Dithiocarbamates: Crystal and Molecular Structure of Dimethyldithiocarbamato(2-phenylazophenyl-C,N')tellurium(II)
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The synthesis of the (2-phenylazophenyl-C,N')tellurium(II)dithiocarbamates TeII(C6H4N2Ph)(dtc) (dtc = dimethyl-, diethyl-, or dibenzyl-dithiocarbamate) is reported.The corresponding series of tris compounds, Te(C6H4N2Ph)(dtc)3 is also reported. 125Te N.m.r. data indicate that the tris compounds dissociate to tellurium(II) compounds in solution and 125Te Moessbauer data suggest that the tris compounds are better formulated as loose charge-transfer compounds TeII(C6H4N2Ph)(dtc).R'2NC(S)S-S(S)CNR'2 (R' = Me, Et, or CH2Ph).The crystal and molecular structure of dimethyldithiocarbamato(2-phenylazophenyl-C,N')tellurium(II) has been determined.The compound crystallises in the monoclinic centrosymmetric space group P21/n with a = 6.225(5), b = 12.133(9), c = 21.784(14) Angstroem, β = 92.88(5) deg, and Z = 4.The refinement converged to R = 0.0517.Tellurium is in a distorted planar environment with Te-C 2.101(8), Te-N 2.340(7), Te-S 2.568(2), and Te...S 3.255(3) Angstroem.Bond angles include STeS 60.9(1), STeC 89.8(2), CTeN 72.5(3), and NTeS 136.3(2) deg.No significant intermolecular contacts are observed.
- Ahmed, Mohammed A. K.,McCarthy, Anne E.,McWhinnie, William R.
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p. 771 - 776
(2007/10/02)
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- Reduction Potentials of Thiuram Disulfide/Dithiocarbamate Couples in Acetone/Water
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Reduction potentials relative to the saturated calomel electrode, Eo, of a series of thiuram disulfide/dithiocarbamate couples have been measured in 30percent v/v water in acetone and at μ 0.2 mol l-1 (NaNO3) by a combination of potentiometric measurements and equilibrium constant determinations for thiolate/disulfide interchange reactions.Eo values lie in the range -250 to -340 mV which place dithiocarbamates as intermediate between thiophenolate (Eo -540 mV) and ethylxanthate (Eo -206 mV) in reducing properties.The significant effect on Eo of varying the substituents on the nitrogen in the dithiocarbamates correlates with the substituent effects on the acid dissociation constants of the parent dithiocarbamic acid and with trends in the half-wave potentials for metal-based oxidation and reduction of transition metal dithiocarbamate complexes.
- Nichols, Peter J.,Grant, Michael W.
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p. 2455 - 2463
(2007/10/02)
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