- New cerebroside and nucleoside derivatives from a red sea strain of the marine cyanobacterium moorea producens
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In the course of our ongoing efforts to identify marine-derived bioactive compounds, the marine cyanobacterium Moorea producens was investigated. The organic extract of the Red Sea cyanobacterium afforded one new cerebroside, mooreaside A (1), two new nucleoside derivatives, 3-acetyl-2′-deoxyuridine (2) and 3-phenylethyl-2′-deoxyuridine (3), along with the previously reported compounds thymidine (4) and 2,3-dihydroxypropyl heptacosanoate (5). The structures of the compounds were determined by different spectroscopic studies (UV, IR, 1D, 2D NMR, and HRESIMS), as well as comparison with the literature data. Compounds 1-5 showed variable cytotoxic activity against three cancer cell lines.
- Youssef, Diaa T.A.,Ibrahim, Sabrin R.M.,Shaala, Lamiaa A.,Mohamed, Gamal A.,Banjar, Zainy M.,Ferreira, Isabel C.F.R.
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- New alkamide and ent-kaurane diterpenoid derivatives from Senecio erechtitoides (Asteraceae)
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Fractionation of a MeOH/CH2Cl2 (1/1) extract of the aerial parts of Senecio erechtitoides led to the isolation of six compounds including the hitherto unknown N-phenethylamide derivative named N-(p-hydroxyphenethyl)pentacosanamide (1), and a kauranoid derivative named derivative named ent-7-oxo-16α,17-dihydroxykauran-19-oic acid (2), as well as four known compounds, ent-Kaur-16-en-19-oic acid (3), ent-7β- hydroxykaur-16-en-19-oic acid (4), ent-7-oxokaur-16-en-19-oic acid (5), steppogenin 4′-O-β-d-glucoside (6). Their structures and relative configurations were elucidated on the basis of spectroscopic methods, chemical reactions, and comparison with previously known analogs. All isolates were evaluated for their antimicrobial activity and only diterpenoids were found to possess a potent inhibitor effect against the range of microorganism.
- Ndom, Jean C.,Mbafor, Joseph T.,Meva'A, Luc M.,Kakam, Zanestsie,Phanuel, Arwa S.,Ndongo, Etienne,Harwood, Laurence M.,Mpondo, Theophile N.
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- Gracilarioside and gracilamides from the Red alga Gracilaria asiatica
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One gracilarioside and two gracilamides with unusual cyclopropane- containing alkyl chains were isolated from the red alga Gracilaria asiatica. Their structures were determined by spectroscopic methods and microscale chemical degradation. To our knowledge, no ceramides with a cyclopropane ring have been reported from marine organisms. These three compounds were mildly cytotoxic to the human A375-S2 melanoma cell line.
- Sun, Yi,Xu, Youjun,Liu, Kai,Hua, Huiming,Zhu, He,Pei, Yuehu
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p. 1488 - 1491
(2008/12/22)
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- A New Synthesis of Long Chain Acid Esters and Carbinols
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A versatile synthesis of difficulty accessible long chain acid esters and carbinols is described.The synthesis involves acylations at 2- and 5-positions of thiophene.Thioketalation of the resulting ketoesters followed by Raney nickel desulfurization yield acid esters which on LAH reduction give the corresponding carbinols.
- Rao, S. Jagadishwar,Bhalerao, U. T.,Tilak, B. D.
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p. 208 - 211
(2007/10/02)
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