55503-43-0Relevant articles and documents
Thienopyridone antibacterials. Part I. A synthesis of some 7-alkyl-2-chloro-1,4-dihydro-4-oxothieno[2,3-6]pyridine-5-carboxylic acids
El-Abadelah, Mustafa M.,Sabri, Salim S.,Al-Ashqar, Haneen A.
, p. 255 - 264 (2007/10/03)
A selected set of 7-alkyl-4-oxothieno[2,3-b]pyridine-5-carboxylic acids (7) and their methyl esters (6) were prepared by cyclization of the respective 3-N-alkylamino-2-(2,5-dichloro-3-thienoyl)acrylates (5) which, in turn, are accessible via methyl 3-(2,5-dichlorothien-3-yl)-3-oxopropanoate (3). Of the present series, the N-cyclopropyl derivative (7b) exhibited the highest potency against Escherichia coli (MIC = 0.5 μg/ml).