- A kind of α-hydroxy amides the synthetic method of the compound of
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The invention provides a method for synthesizing an alpha-hydroxy amide compound. The method specifically comprises the following steps: (1) mixing amide, an alkali and dimethyl sulfoxide, sealing in an air atmosphere, and reacting; (2) cooling to room te
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Paragraph 0128-0136
(2016/10/07)
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- Superacid-promoted reactions of α-ketoamides and related systems
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(Chemical Equation Presented) The superacid-promoted reactions of α-hydroxy and α-ketoamides have been studied. Ionization of these compounds leads to varied aryl-substituted oxyindole products. In some cases, electrocyclization can lead to substituted fl
- Sai, Kiran Kumar Solingapuram,Esteves, Pierre M.,Da Penha, Eduardo Tanoue,Klumpp, Douglas A.
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p. 6506 - 6512
(2008/12/22)
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- Nucleophilic Addition of Lanthanoid Metal Umpoled Diaryl Ketones to Electrophiles
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Ytterbium metal promoted cross-coupling reactions of diaryl ketones with a variety of electrophiles are described.Diaryl ketones treated with 1-2 equiv of Yb metal react smoothly with other ketones, nitriles, epoxides, CO2, etc., to give the corresponding unsymmetrical pinacols, α-hydroxy ketones, 1,3-diols, α-hydroxy carboxylic acids, etc., in good yields respectively.These reactions occur via nucleophilic addition of the intermediates 4a-c to electrophiles.Reaction of benzophenone (1a) with Yb metal is discussed in detail and some information on the composition of the intermediates of the reaction of diaryl ketones with Yb metal are also given.
- Hou, Zhaomin,Takamine, Kan,Aoki, Osamu,Shiraishi, Hiroyuki,Fujiwara, Yuzo,Taniguchi, Hiroshi
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p. 6077 - 6084
(2007/10/02)
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- Synthesis of α-Hydroxycarboxamides from Acetonides of α-Hydroxycarboxylic Acids and Primary Amines
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The reaction of acetonides of α-hydroxycarboxylic acids with primary amines on heating provides a useful synthetic route to N-substituted α-hydroxycarboxamides.In general, formation of the α-hydroxycarboxamides is favored by the presence of only small sub
- Khalaj, A.,Nahid, E.
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p. 1153 - 1155
(2007/10/02)
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