Br?nsted Acid-Catalyzed Asymmetric Ring-Closing Alkylation of Inert N-substituted Pyrroles with α, β-Unsaturated Ketones
A Chiral Br?nsted acid catalyzed asymmetric intramolecular ring-closing alkylation of inert pyrroles with α, β-unsaturated ketones has been developed. This approach gave a wide range of 4-phenyl-4,5-dihydro-6H-benzo[f]pyrrolo[1,2-a]azepin-6-ones in high yields with good enantioselectivities under mild reaction conditions. (Figure presented.).
Solvent and ligand effects on selective mono- and dilithiation of 1-(chlorophenyl)pyrroles and 1-(methoxyphenyl)pyrroles
Novel methods for site-selective lithiation of 1-(chlorophenyl)pyrroles and 1-(methoxyphenyl)pyrroles are described. Mono- or dilithiations are governed by change of both the temperature and the solvent from tetrahydrofuran to diethyl ether. Regioselectiv
Fogassy, Katalin,Kovacs, Krisztina,Keseru, Gyoergy M.,Toke, Laszlo,Faigl, Ferenc
p. 1039 - 1043
(2007/10/03)
Tricyclic oxime ethers
The present invention relates to compounds of formula (I): STR1 wherein A, x, y, R1, R2 and R3 are as defined in the description. The compounds are useful for treating diseases requiring a selective serotonin reuptake site
A series of 1 (2 carboxyphenyl) pyrroles and their cyclized derivatives, pyrrolo [1,2 a]indoles, was synthesized and screened for hypoglycemic activity in rats. 1 (2 Carboxy 3 chlorophenyl) pyrrole was the most active, but had side effects.
Sugihara,Matsumoto,Hamuro,Kawamatsu
p. 1560 - 1563
(2007/10/06)
More Articles about upstream products of 55540-33-5