Efficient methods for optional metalation of 1-(methylphenyl)pyrroles in α or benzylic positions
Novel, selective metalation methods have been described for optional functionalisation of 1-(methylphenyl)pyrroles in α or benzylic positions and an efficient way for dilithiation of the model compounds has also been reported.
4-Acetoxypyrroloquinolines 26-30 were synthesized by cyclization of 2-(1-pyrrolyl)phenylacetic acids 21-25 with acetic anhydride.The structures of the new compounds were determined by 1H-nmr spectroscopy.
Bouyazza, Lahboub,Lancelot, Jean-Charles,Rault, Sylvain,Robba, Max
A series of 1 (2 carboxyphenyl) pyrroles and their cyclized derivatives, pyrrolo [1,2 a]indoles, was synthesized and screened for hypoglycemic activity in rats. 1 (2 Carboxy 3 chlorophenyl) pyrrole was the most active, but had side effects.
Sugihara,Matsumoto,Hamuro,Kawamatsu
p. 1560 - 1563
(2007/10/06)
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