- Syntheses and structures of N,N′-bis(6-(2-hydroxymethyl)pyridylmethyl)piperazine, its two zinc(II) complexes and the cadmium(II) complex of N-(6-(2-hydroxymethyl)pyridylmethyl)-N′-(2-pyridylmethyl)piperazine
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The syntheses and crystal structures of N,N′-bis(6-(2-hydroxymethyl)-pyridylmethyl)piperazine (C18H24N4O2, 3), its polymeric zinc(II) nitrate complex (C18H29N7O14Zn2, 3a) and dinuclear zinc(II) chloride complex (C20H27N5O2Zn2Cl 4, 3b) and mononuclear cadmium(II) nitrate complex of N-(6-(2-hydroxymethyl)pyridylmethyl)-N′-(2-pyridylmethyl)piperazine (C17H22N6O7Cd, 4a) are described. Compound 3 was characterised by 1H and 13C NMR, mass spectrometry and elementary analysis. The structures of all compounds were determined by single crystal X-ray diffraction methods. Crystal data: 3: monoclinic, space group P21/n (no. 14), a=7.816(1), b=6.699(1), c= 16.567(3) A, β=91.94(1)°, V=866.9(2) A3, Z=2; 3a: monoclinic, space group P2/n (no. 13), a=10.274(1), b=11.018(1), C=11.615(1) A, β=93.13(1)°, V= 1312.8(2) A3, Z=2; 3b: triclinic, space group P1 (no. 2), a=9.624(1), b= 11.381(1), c=14.016(1) A, α=106.21(1), β=102.73(1), γ=107.10(1)°, V= 1323.9(2) A3, Z=2; 4a: monoclinic, space group P21/c (no. 14), a=13.589(8), b=9.006(5), c=17.472(8) A, β=101.96(4)°, V=2092(2) A3, Z=4. In the metal complexes, zinc has a distorted square-pyramidal coordination and cadmium has a pentagonal bipyramidal coordination. In 3a and 3b, three coordination sites are occupied by one oxygen and two nitrogens of hexadentate 3 and the remaining two by the bridging hydroxyl group and a terminal water molecule in 3a and by two terminal chlorine atoms in 3b. In 4a, five coordination sites of cadmium are occupied by four nitrogens and one oxygen of the pentadentate ligand, and the remaining two by monodentate nitrate groups. Acta Chemica Scandinavica 1998.
- Loukiala, Satumari,Ratilainen, Jari,Airola, Karri,Valkonen, Jussi,Rissanen, Kari
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p. 593 - 602
(2007/10/03)
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- Regioselective complexation of new multiple piperazine/pyridine ligands: differentiation by113Cd-NMR spectroscopy
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Eleven novel piperazine containing open-chain ligands L1-L11 were designed to offer symmetrical and asymmetrical complexation sites for metal ions and were synthesized by repetitive synthetic method. The divergent use of aromatic bishalomethyl and mono-Af-alkylated piperazine compounds as spacers led to a series of long (up to M. W. = 836) oligomeric multidentate N-ligands. Due to the lack of solid state methods for structure analysis, an NMR technique using 113Cd nucleus as a probe in solution state was utilised. 113Cd chemical shifts were observed to be dependend on the coordination site and similar coordination sites in different ligands gave characteristically similar 113Cd chemical shifts. As a result 113Cd-NMR spectroscopy proved to be an excellent tool to distinguish between the structures of the different complexation sites on a nearly quantitative level. VCH Verlagsgesellschaft mbH,.
- Ratilaincn, Jari,Airola, Karri,Kolehmaincn, Erkki,Rissanen, Kari
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p. 1353 - 1359
(2007/10/03)
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- (2-Alkyl-3-pyridyl)methylpiperazine derivatives as PAF antagonists
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The present invention relates to new (2-alkyl-3-pyridyl) methylpiperazine derivatives of general formula I: wherein R1, R2 and Z are as defined in Claim 1. The invention also relates to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent, orally active PAF antagonists and, consequently, they are useful in the treatment of the diseases in which this substance is involved.
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