- Synthesis and anthelmintic activity of 7-hydroxy-5-oxo-5H-thieno[3,2- b]pyran-6-carboxanilides and -6-thiocarboxanilides
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7-Hydroxy-5-oxo-5H-thieno[3,2-b]pyran-6-carboxanilides and -6- thiocarboxanilides represent a novel series of anthelmintic compounds, with broad-spectrum activity against important parasitic nematodes in sheep and dogs. In particular, an improved efficacy against Trichostrongylus colubriformis in sheep over the related 3-carbamoyl-4-hydroxycoumarins has been noted. New synthetic routes to the key intermediate, 7- hydroxythieno[3,2-b]pyran-5-one, have been developed.
- Plant,Harder,Mencke,Bertram
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p. 351 - 358
(2007/10/03)
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- A NEW GENERAL SYNTHESIS OF 2-(N-MONO- AND N-DI-SUBSTITUTED AMINO)THIAZOLES
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Although α-mercapto ketones react with cyanamides to give substituted 2-aminothiazoles the yields are satisfactory in only the simplest cases.However, a range of 2-aminothiazoles with substituents on the ring or the exo-nitrogen atom was obtained efficiently by the following one-pot procedure: a solution of an α-mercapto ketone anion was generated by treating an O-ethyl S-2-oxoethyl dithiocarbonate with piperidine at 20 deg C, a cyanamide was added, and the solution was heated for 3-6 h.
- Brown, Michael D.,Gillon, David W.,Meakins, G. Denis,Whitham, Gordon H.
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p. 1623 - 1626
(2007/10/02)
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