Benzamide synthesis by direct electrophilic aromatic substitution with cyanoguanidine
Cyanoguanidine is an inexpensive commodity chemical and it is found to be a useful reagent for the direct Friedel-Crafts carboxamidation of arenes. The reaction works best in an excess of Bronsted superacid, an observation suggesting the involvement of a superelectrophilic intermediate. Theoretical calculations indicate that the most stable diprotonated species involves protonation at the guanidine and cyano nitrogen atoms.
Naredla, Rajasekhar Reddy,Klumpp, Douglas A.
experimental part
p. 4779 - 4781
(2012/09/07)
Quantitative structure-activity analysis of larvicidal 1-(substituted benzoyl)-2-benzoyl-1-tert-butylhydrazines against Chilo suppressalis
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Oikawa,Nakagawa,Nishimura,Ueno,Fujita
p. 139 - 148
(2007/10/03)
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