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1H-Benzimidazole-2-carboxaldehyde,1-(cyclopropylmethyl)-(9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 558446-33-6 Structure
  • Basic information

    1. Product Name: 1H-Benzimidazole-2-carboxaldehyde,1-(cyclopropylmethyl)-(9CI)
    2. Synonyms: 1H-Benzimidazole-2-carboxaldehyde,1-(cyclopropylmethyl)-(9CI)
    3. CAS NO:558446-33-6
    4. Molecular Formula: C12H12N2O
    5. Molecular Weight: 200.23648
    6. EINECS: N/A
    7. Product Categories: BENZIMIDAZOLE
    8. Mol File: 558446-33-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-Benzimidazole-2-carboxaldehyde,1-(cyclopropylmethyl)-(9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-Benzimidazole-2-carboxaldehyde,1-(cyclopropylmethyl)-(9CI)(558446-33-6)
    11. EPA Substance Registry System: 1H-Benzimidazole-2-carboxaldehyde,1-(cyclopropylmethyl)-(9CI)(558446-33-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 558446-33-6(Hazardous Substances Data)

558446-33-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 558446-33-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,5,8,4,4 and 6 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 558446-33:
(8*5)+(7*5)+(6*8)+(5*4)+(4*4)+(3*6)+(2*3)+(1*3)=186
186 % 10 = 6
So 558446-33-6 is a valid CAS Registry Number.

558446-33-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-cyclopropylmethyl-1H-benzoimidazole-2-carbaldehyde

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:558446-33-6 SDS

558446-33-6Downstream Products

558446-33-6Relevant articles and documents

Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity

Ma, Zonghui,Jiang, Ling,Li, Bingyan,Liang, Dailin,Feng, Yu,Liu, Li,Jiang, Cheng

, (2021/08/17)

Aldehyde dehydrogenase 1A1 (ALDH1A1) plays vital physiological and toxicological functions in many areas, such as CNS, inflammation, metabolic disorders, and cancers. Overexpression of ALDH1A1 has been disclosed to play an important role in obesity, diabetes and other diseases, indicating the potential need for the identification and development of small molecule ALDH1A1 inhibitors. Herein, a series of benzimidazole derivatives was designed, synthesized and evaluated. Among them, compounds 21, 27, 29, 61 and 65 exhibited excellent inhibitory activity against ALDH1A1 with IC50 values in the low micromolar range and high selectivity over ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1. Moreover, an in vitro study demonstrated that all five compounds effectively improved glucose consumption in HepG2 cells, of which, 61 and 65 at 10 μM produced nearly equal glucose consumption with positive control Metformin (Met) at 1 mM. Furthermore, 61 and 65 showed desirable metabolic stability in human liver microsomes. All these results suggest that 61 and 65 are suitable for further studies.

Chemokine receptor binding heterocyclic compounds with enhanced efficacy

-

, (2008/06/13)

The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

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