558478-65-2Relevant articles and documents
1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1
Rahman, Shahzad S.,Coulton, Steven,Herdon, Hugh J.,Joiner, Graham F.,Jin, Jian,Porter, Roderick A.
, p. 1741 - 1745 (2008/02/11)
High throughput screening led to the discovery of a novel series of 1,3-diaminopropan-2-ol sulfonamides as selective GlyT-1 inhibitors. Structure-activity relationships of this novel series and optimisation of the initial hit that led to the identificatio
GLYT1 TRANSPORTER INHIBITORS
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Page/Page column 38-39, (2010/02/12)
The invention provides a compound of formula (I): or a salt, solvate or a physiologically functional derivative thereof, wherein R1 to R10 are as defined in the specification and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
