CuI catalyzed domino coupling–cyclization of 2-iodo-phenols and 1-alkynes to the synthesis of 2-substituted benzo[b]furans/furo-pyridines
CuI/proline-catalyzed coupling reaction of 2-iodo-phenols with terminal alkynes and the following cyclization process is carried out successively in DMSO at 80 °C. Under this tandem process, 2-substituted benzo[b]furans/furo-pyridines were synthesized in good to excellent yields with a great diversity.
Chen, Ze-Pin,Zhou, Yi,Shui, Meng-Zhu,Liu, Feng
supporting information
p. 133 - 136
(2018/12/11)
PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES
The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, a compound of formula (3), an intermediate in the preparation of Dronedarone. The present invention further provides a process for preparing Dronedarone, comprising the steps of converting 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) to Dronedarone, wherein the 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) is prepared by the processes of the present invention.
-
(2011/09/15)
Intramolecular Cycloaddition of Ketenes to Carbonyl Groups. A Novel Synthesis of Substituted Benzofurans
-
Brady, William T.,Giang, Yun-seng F.,Marchand, Alan P.,Wu, An-hsiang
p. 3457 - 3461
(2007/10/02)
Pharmaceutical compositions and methods of producing coronary vasodilation
Pharmaceutical compositions and methods of producing coronary vasodilation by administering substituted benzofurans, for example 2-n-butyl-3-[4' -(2-hydroxy-3-isopropylamino)propoxybenzoyl] benzofuran.
-
(2008/06/13)
More Articles about upstream products of 55877-57-1