- New modes for the osmium-catalyzed oxidative cyclization
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(Figure Presented) The osmium-catalyzed oxidative cyclization of amino alcohol initiators formally derived from 1,4-dienes Is an effective method for the construction of pyrrolidines, utilizing a novel reoxidant (4-nltropyridlne N-oxide = NPNO). The cyclization of enantlopure syn- and anti-amino alcohols gives rise to enantlopure cis- and frans-2,5-disubstituted pyrrolidines, respectively. Moreover, the cyclization of Ws-homoallylic amines bearing an exocyclic chelating group Is shown to be a complementary method for irans-pyrrolidine formation.
- Donohoe, Timothy J.,Lindsay-Scott, Peter J.,Parker, Jeremy S.,Callens, Cedric K. A.
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supporting information; experimental part
p. 1060 - 1063
(2010/06/13)
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