cas 55983-75-0, 3-carboxy-1-(3-chlorophenyl)-5-methoxypyrazole | Articles data ｜lookchem

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55983-75-0

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Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl) methanamines as potent and efficacious type II calcimimetics
Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment of secondary hyperparathyroidism focused on the development of ring constrained analogues of the known calcimimetic R-568. The structure-activity relationships of various substituted heterocycles and their effects on the human calcium-sensing receptor are discussed. Pyrazole 15 was shown to be efficacious in a rat in vivo pharmacodynamic model.
Poon, Steve F.,St Jean Jr., David J.,Harrington, Paul E.,Henley III, Charles,Davis, James,Morony, Sean,Lott, Fred D.,Reagan, Jeff D.,Lu, Jenny Ying-Lin,Yang, Yuhua,Fotsch, Christopher
supporting information; experimental part
p. 6535 - 6538
(2010/04/03)

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Chemical Properties

Boiling Point: 449.5°Cat760mmHg
Flash Point:225.6°C
Density: 1.42g/cm³
Vapor Pressure: 7.26E-09mmHg at 25°C
PKA: 3.71±0.10(Predicted)
PSA: 64.35000
LogP: 2.23250

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