Synthesis and conformational studies on 3-o-tolylhydantoins by NMR and molecular modeling: Dipole-π attractions in peptides and proteins
5-Pentafluorobenzyl-3-o-tolylhydantoin (2) was synthesized for reducing this π-electron density, and NMR studies have shown that we have succeeded in changing the conformation of 2 into an extended system instead of the folded conformation for the non-fluorinated compound, 5-benzyl-3-o-tolylhydantoin (1). Molecular modeling has also confirmed the extended structure for 2. An approach has been found for possibly modulating the physiological activity of peptides containing aromatic amino acids.
Park, Sang Hyun,Bose, Ajay K.
p. 1917 - 1925
(2007/10/03)
A New Method of Synthesis of 3-Monosubstituted-2-thiohydantoins and -Hydantoins
A new method of synthesis of 3-monosubstituted derivatives of 2-thiohydantoin and hydantoin in reaction of isothiocyanate or isocyanate glycin ethyl ester with primary aliphatic and aromatic amines has been described. Crude products were obtained with high yield and purity. The structure of these compounds was confirmed by spectral methods. Key words: 2-thiohydantoin, hydantoin, isothiocyanate glycin ethyl ester, isocyanate glycin ethyl ester
Ryczek, J.
p. 2599 - 2604
(2007/10/02)
A New Convenient Synthesis of Hydantoin Derivatives by the Phase-Transfer Method
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Suk-Choong Kim,Byoung-Mog Kwon
p. 795 - 796
(2007/10/02)
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