- Monitoring Ligand Substitution in (Catalytically Active) Metal Complexes with Bodipy-Tagged Diimines and NHC Ligands
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The reaction of 2,6-dimethyl-4-(Bodipy-8-yl)aniline with 1,4-dioxane-2,3-diol provides the respective diimine 3, followed by ring closure with paraformaldehyde, resulting in the imidazolium salt 4·HCl containing two fluorophores. The NHC metal complexes (
- Halter, Oliver,Spielmann, Jonas,Kanai, Yuki,Plenio, Herbert
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Read Online
- Synthetic method of rilpivirine intermediate
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The invention provides a synthetic method of a rilpivirine intermediate. The synthesis method includes: taking 2, 4, 6-trimethylaniline as the raw material to react with 2, 3-dichloro-5, 6-dicyanobenzoquinone (DDQ) in a diluted hydrochloric acid solution
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Paragraph 0026-0028; 0031-0032
(2020/07/12)
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- Pyrimidine heterocyclic compounds, pyrimidine heterocyclic compound salts, and preparation method and application thereof
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The invention provides pyrimidine heterocyclic compounds, pyrimidine heterocyclic compound salts, and a preparation method and application thereof. According to the pyrimidine heterocyclic compounds provided by the invention, specific Rq is selected, so that the obtained compounds have favorable drug resistance and long half life when being used as the medicine for treating or preventing HIV. The compounds have the advantages of high activity, low toxicity and high stability.
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Paragraph 0243; 0244; 0245; 0246
(2017/07/26)
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- Regiospecific oxidation of an alkyl group of aromatic amine to carbonyl group by DDQ in aq. medium
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The regiospecific oxidation of alkyl group of both sterically hindered and unhindered aromatic amine to corresponding carbonyl compound was done in aq. medium by using DDQ. The optimized reaction protocol was found to be most simple, high yielding and novel method for oxidation of alkyl group of aromatic amine in to its carbonyl compound.
- Mane, Madhav S.,Balaskar, Ravi S.,Gavade, Sandip N.,Pabrekar, Pramod N.,Shingare, Murlidhar S.,Mane, Dhananjay V.
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experimental part
p. 1039 - 1042
(2012/06/01)
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- Hydrogenated Benzo (C) Thiophene Derivatives as Immunomodulators
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The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
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Page/Page column 18
(2008/12/07)
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- COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES
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The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.
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Page/Page column 45
(2008/12/07)
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- HYDROGENATED BENZO (C) THIOPHENE DERIVATIVES AS IMMUNOMODULATORS
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The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
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Page/Page column 50
(2010/11/24)
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- Simple Synthetic Route to 4-Aminobenzaldehydes from Anilines
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Anilines unsubstituted at the 4-position react under mild conditions in Me2SO-HCl solvent (H+ = 0.6 mol dm-3) to give substituted 4-aminobenzaldehydes in high yields; although addition of CuCl2 gives a cleaner product, it is not esse
- Liedholm, Brita
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p. 2235 - 2242
(2007/10/02)
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- 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
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2,4-Diamino-5-benzylpyrimidines of the formula STR1 wherein R1, R2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, t
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- REGIOSPECIFIC OXIDATION BY DDQ OF UNHINDERED ALKYL GROUPS IN STERICALLY HINDERED AROMATIC AMINES
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DDQ oxidises an unhindered activated alkyl group to a carbonyl or a hydroxymethyl group depending on the nature of the substitution, in a sterically hindered aromatic amine.
- Lal, Bansi,Gidwani, Ramesh M.,Reden, Jurgen,Souza, Noel J. de
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p. 2901 - 2904
(2007/10/02)
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