Design and synthesis of novel sulfonamide-containing bradykinin hB 2 receptor antagonists. Synthesis and structure-relationships of α,α-tetrahydropyranylglycine
A series of α,α-cycloalkylglycine sulfonamide compounds of general formula 1 has previously been identified by our group as selective human B2(hB2) receptor antagonists. Here we report the in vitro and in vivo BK antagonist activity
Fincham, Christopher I.,Bressan, Alessandro,D'Andrea, Piero,Ettorre, Alessandro,Giuliani, Sandro,Mauro, Sandro,Meini, Stefania,Paris, Marielle,Quartara, Laura,Rossi, Cristina,Squarcia, Antonella,Valenti, Claudio,Daniela, Fattori,Maggi, Carlo Alberto
supporting information; experimental part
p. 2091 - 2100
(2012/05/05)
3-oxo-2(H)-1,2,4-triazine derivatives as ligands of 5 HT1A receptors
The invention concerns novel 3-oxo-(2H)-1,2,4-triazine derivatives of general formula (I) in which R1represents: hydrogen, when A is an optionally substituted nitrogen atom; a linear or branched1-C4alkyl group; a C1/
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(2008/06/13)
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