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56323-44-5

1-(2-chloroethyl)-3-[(1R,3R)-3-hydroxycyclohexyl]-1-nitrosourea, commonly known as nimustine, is an alkylating chemotherapeutic agent characterized by its ability to treat specific types of brain cancer. It operates through the mechanism of damaging the DNA of cancer cells, leading to their destruction. 1-(2-chloroethyl)-3-[(1R,3R)-3-hydroxycyclohexyl]-1-nitrosourea is particularly effective against gliomas, which are tumors that originate in the brain or spinal cord. Notably, nimustine has demonstrated the capacity to penetrate the blood-brain barrier, a significant advantage for brain tumor treatments. It also distinguishes itself with a relatively high tolerability and low toxicity profile when compared to other chemotherapeutic agents.

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  • 56323-44-5 Structure

  • Basic information

    1. Product Name: 1-(2-chloroethyl)-3-[(1R,3R)-3-hydroxycyclohexyl]-1-nitrosourea
    2. Synonyms:
    3. CAS NO:56323-44-5
    4. Molecular Formula: C9H16ClN3O3
    5. Molecular Weight: 249.6946
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 56323-44-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: 1.46g/cm3
    6. Refractive Index: 1.605
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(2-chloroethyl)-3-[(1R,3R)-3-hydroxycyclohexyl]-1-nitrosourea(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(2-chloroethyl)-3-[(1R,3R)-3-hydroxycyclohexyl]-1-nitrosourea(56323-44-5)
    11. EPA Substance Registry System: 1-(2-chloroethyl)-3-[(1R,3R)-3-hydroxycyclohexyl]-1-nitrosourea(56323-44-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 56323-44-5(Hazardous Substances Data)

56323-44-5 Usage

Uses

Used in Oncology:
Nimustine is utilized as an anticancer agent, specifically targeting brain cancers such as gliomas. It is effective due to its ability to cross the blood-brain barrier, a critical feature for treating tumors in the brain and spinal cord. The drug's alkylating action disrupts the DNA of cancer cells, causing their destruction and thereby inhibiting tumor growth and progression.
Used in Comparative Chemotherapy:
Nimustine is also used in comparative studies within the field of chemotherapy. Its high tolerability and low toxicity make it a valuable agent for assessing the safety and efficacy of other chemotherapeutic drugs. This comparison can lead to the development of more effective and less harmful treatments for brain cancer patients.

Check Digit Verification of cas no

The CAS Registry Mumber 56323-44-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,3,2 and 3 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 56323-44:
(7*5)+(6*6)+(5*3)+(4*2)+(3*3)+(2*4)+(1*4)=115
115 % 10 = 5
So 56323-44-5 is a valid CAS Registry Number.

56323-44-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name trans-3-Hydroxy CCNU

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:56323-44-5 SDS

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