56341-40-3

Basic information

• Product Name: 7-TRIFLUOROMETHYLOXINDOLE
• Synonyms: 7-TRIFLUOROMETHYLOXINDOLE;7-(trifluoromethyl)indolin-2-one;7-Trifluoromethyl-2-oxindole;7-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one(SALTDATA: FREE);7-(Trifluoromethyl)-1,3-dihydro-2H-indol-2-one;7-(trifluoromethyl)-1,3-dihydroindol-2-one;7-(trifluoromethyl)-2-indolinone
• CAS NO: 56341-40-3
• Molecular Formula: C₉H₆F₃NO
• Molecular Weight: 201.15
• EINECS: 1312995-182-4
• Product Categories: blocks;FluoroCompounds;IndolesOxindoles;Indoline & Oxindole
• Mol File: 56341-40-3.mol

Chemical Properties

• Boiling Point: 284 °C at 760 mmHg
• Flash Point: 125.5 °C
• Appearance: /
• Density: 1.391g/cm³
• Vapor Pressure: 0.00306mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: 2-8°C
• PKA: 13.30±0.20(Predicted)
• CAS DataBase Reference: 7-TRIFLUOROMETHYLOXINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-TRIFLUOROMETHYLOXINDOLE(56341-40-3)
• EPA Substance Registry System: 7-TRIFLUOROMETHYLOXINDOLE(56341-40-3)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 56341-40-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
7-Trifluoromethyloxindole is used as a building block and intermediate for the synthesis of biologically active molecules, contributing to the development of new drugs with enhanced properties.
Used in Medicinal Chemistry:
7-Trifluoromethyloxindole is utilized in the design of novel pharmaceuticals, leveraging its unique reactivity and properties to improve biological activity and pharmacokinetics.
Used in Drug Discovery:
7-Trifluoromethyloxindole plays a role in drug discovery processes, aiding in the identification and development of new therapeutic agents with potential applications in various medical fields.

InChI:InChI=1/C9H6F3NO/c10-9(11,12)6-3-1-2-5-4-7(14)13-8(5)6/h1-3H,4H2,(H,13,14)

Upstream product

• 391-12-8 7-trifluoromethylisatin 
• 59-48-3 2-oxoindole 
• 2926-29-6 Langlois reagent 

Downstream Products

• 1374637-29-2 2,6-diphenyl-7'-trifluoromethylspiro[cyclohexane-1,3'-indoline]-2',4-dione 

Relevant articles and documents

A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids

A novel method for the synthesis of 3-monohalooxindoles by acidolysis of isatin-derived 3-phosphate-substituted oxindoles with haloid acids was developed. This synthetic strategy involved the preparation of 3-phosphate-substituted oxindole intermediates and SN1 reactions with haloid acids. This new procedure features mild reaction conditions, simple operation, good yield, readily available and inexpensive starting materials, and gram-scalability.

Visible-Light Mediated ortho-Trifluoromethylation of Aniline Derivatives

A general visible-light mediated ortho-C-H trifluoromethylation of aniline derivatives by using a low-cost and stable Langlois reagent (CF3SO2Na) as the "CF3" source has been developed. In contrast to previous reports, this strategy allowed access to elusive trifluoromethyl lactams. Furthermore, mechanism experiments revealed that a copper/photoredox dual catalytic mechanism enabled general trifluoromethylation of aniline derivatives.

Selective reduction of carbonyl groups in the presence of low-valent titanium reagents

The chemoselective reduction of several structurally diverse compounds containing carbonyl groups was achieved in the presence of low-valent titanium reagents. This novel synthetic method provides easy access to highly selective reduction of carbonyl groups, and possesses several advantages including one-step procedure, convenient manipulation, good to excellent yields, and short reaction times.

Oxindoles as sleep-inducers

Sleep inducers of the formula: STR1 wherein R is hydrogen or halo of atomic weight of from 18 to 36, R' is hydrogen, halo or CF3 and R° is hydrogen or lower alkyl. Preparation by cyclizing a 2-nitro-phenylacetic acid is also disclosed.