- Synthesis of Fluorescent Indazoles by Palladium-Catalyzed Benzannulation of Pyrazoles with Alkynes
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The synthesis of indazoles from pyrazoles and internal alkynes is described. Instead of complex benzenoid compounds, readily available pyrazoles were used for the preparation of indazoles by reaction of the C-H bonds of the heterocyclic ring. Oxidative benzannulation was also applied to imidazoles, providing benzimidazoles. This convergent strategy enabled alteration of the photochemical properties of benzo-fused diazoles by varying the substituents at the benzene ring, thus leading to the development of tetraarylindazoles as new fluorophores.
- Kim, Og Soon,Jang, Jin Hyeok,Kim, Hyun Tae,Han, Su Jin,Tsui, Gavin Chit,Joo, Jung Min
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- Regioselective C-H alkenylation of imidazoles and its application to the synthesis of unsymmetrically substituted benzimidazoles
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A palladium-catalyzed C-H alkenylation of imidazoles has been developed. High C5 selectivity was achieved for C2-unsubstituted and C2-substituted imidazoles using oxygen and copper(ii) acetate, respectively, as oxidants. The obtained products were applied
- Kim, Hyeongwoo,Hwang, Ye Ji,Han, Inhyuk,Joo, Jung Min
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supporting information
p. 6879 - 6882
(2018/06/26)
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- Polyfunctional imidazolium surfactant and preparation method thereof
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The invention discloses a polyfunctional imidazolium surfactant and a preparation method thereof. The preparation method comprises the following steps: 1) preparing an alkyl-substituted imidazole intermediate; 2) preparing a bromo-oligomer intermediate; and 3) under nitrogen protection, adding the alkyl-substituted imidazole intermediate, the bromo-oligomer intermediate and acetonitrile in a reaction bottle, stirring the materials, heating the materials and performing backflow, reacting the materials, cooling the materials to room temperature, and removing a solvent to obtain the tri-imidazolium surfactant. Compared with the prior art, the tri-imidazolium surfactant has excellent performance, has three imidazolium groups, and greatly enhances the hydrophilic performance of the surfactant.The tri-imidazolium surfactant can adjust an amount of a monomer, effectively controls a size of a hydrophobic group in the surfactant molecules, and is in favor of regulating and controlling the performance of the surfactant. The preparation method of the tri-imidazolium surfactant has the advantage of simple process, and the obtained product has the advantages of easy separating and purifying, less by-product, and environmentally friendly performance.
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Paragraph 0035; 0036
(2018/09/12)
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- Neurokinin-3 receptor modulators: diaryl imidazole derivatives
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The invention relates to compounds of general Formula I: wherein the variables are as defined herein. Also provided are pharmaceutical compositions comprising such compounds, and methods for treating patients suffering from a disorder responsive to neurok
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Page/Page column 20
(2010/02/12)
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- Activity of new iminium compounds against bacteria and fungi strains. Part 28: Synthesis of 1-ethyl-, 1-n-decyl-2-phenyl-3-(n-alkylthiomethyl)- and 1-ethyl, 1-n-dodecyl-2-phenyl-3-(n-alkoxymethyl)imidazolium chlorides
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The synthesis of quaternary imidazolium compounds was performed by reaction of 1-ethyl- or 1-n-dodecyl-2-phenylimidazole with chloromethyl-n-alkyl ether or chloromethyl-n-alkyl sulfid. The antibacterial properties of the compounds obtained were tested on
- Pernak,Krysinski,Skrzypczak
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p. 623 - 626
(2007/10/02)
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