- TREATMENT OF URINARY INCONTINENCE BY ADMINISTRATION OF ALPHA 1L-ADRENOCEPTOR AGONISTS
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The present invention relates to the use of α lL-agonists for treating urinary incontinence.
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- Method of preparing 2-(phenylamino)-imidazolines-(2)
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A process for preparing compounds of the formula: STR1 or pharmaceutically acceptable salts thereof, wherein R1 and R2 each individually are hydrogen, halogen, or nitro, which comprises the steps of: (a) alkylating a compound of the formula: STR2 wherein R3 is C1 to C4 alkyl or phenyl, with a compound of the formula: wherein R4 is C1 to C6 alkyl or phenyl-alkyl where the alkyl is C1 to C4 and X is halogen, in the presence of a base to yield a compound of the formula: STR3 and; (b) cyclizing the compound formed during step (a) with ethylenediamine mono-p-toluenesulphonate at a temperature of 100° to 200° C. to yield the desired product. New intermediate compounds are also disclosed. The desired products have antihypertensive properties.
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- Propargyl-substituted 2-phenylamino-2-imidazolines and salts thereof
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Compounds of the formula STR1 wherein R1, R2 and R3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy or trifluoromethyl, and R4 and R5 are each hydrogen or propargyl, but other than both hydrogen or both propargyl at the same time, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics and hypotensives.
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