- A shan tiefen derivative and its synthetic method and application in pesticide
-
The invention relates to a shan tiefen derivative and its synthetic method and in pesticide application, especially in the application of the pesticide in the fungicide, which belongs to the technical field of agricultural chemicals. The invention solves the technical problem is to provide a new shan tiefen derivative and its synthetic method and in pesticide application, the structure of this compound is shown as formula I. This compound the structure is simple, novel, easy to synthesize, at the same time having fungicidal activity, the tomato alteso, zones all of tomato, cucumber wilt disease, magnaporthe grisea, galenical such important plant pathogenic fungi, have better bacteriostatic or bactericidal effect.
- -
-
Paragraph 0075-0078
(2019/07/08)
-
- Semisynthetic Phenol Derivatives Obtained from Natural Phenols: Antimicrobial Activity and Molecular Properties
-
Semisynthetic phenol derivatives were obtained from the natural phenols: thymol, carvacrol, eugenol, and guaiacol through catalytic oxychlorination, Williamson synthesis, and aromatic Claisen rearrangement. The compounds characterization was carried out by 1H NMR, 13C NMR, and mass spectrometry. The natural phenols and their semisynthetic derivatives were tested for their antimicrobial activity against the bacteria: Staphylococcus aureus, Escherichia coli, Listeria innocua, Pseudomonas aeruginosa, Salmonella enterica Typhimurium, Salmonella enterica ssp. enterica, and Bacillus cereus. Minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values were determined using concentrations from 220 to 3.44 μg mL-1. Most of the tested compounds presented MIC values ≤220 μg mL-1 for all the bacteria used in the assays. The molecular properties of the compounds were computed with the PM6 method. Through principle components analysis, the natural phenols and their semisynthetic derivatives with higher antimicrobial potential were grouped.
- Pinheiro, Patrícia Fontes,Menini, Luciana Alves Parreira,Bernardes, Patrícia Campos,Saraiva, Sérgio Henriques,Carneiro, José Walkimar Mesquita,Costa, Adilson Vidal,Arruda, Társila Rodrigues,Lage, Mateus Ribeiro,Gon?alves, Patrícia Martins,Bernardes, Carolina De Oliveira,Alvarenga, Elson Santiago,Menini, Luciano
-
p. 323 - 330
(2018/01/17)
-
- 2,5-DIALKYL-4-H/HALO/ETHER-PHENOL COMPOUNDS
-
The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): wherein R2, R4, R5, and R6, are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating neurological conditions.
- -
-
Paragraph 0153
(2016/12/22)
-
- 2,5-DIALKYL-4-H/HALO/ETHER-PHENOL COMPOUNDS
-
The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): wherein R2, R4, and R5, are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating neurological conditions.
- -
-
Paragraph 0191
(2015/06/03)
-
- Identification and structure-activity relationship study of carvacrol derivatives as Mycobacterium tuberculosis chorismate mutase inhibitors
-
In the present study, we identified carvacrol, a major phenolic component of oregano oil as a novel small molecule inhibitor of Mycobacterium tuberculosis (MTB) chorismate mutase (CM) enzyme with IC50 of 1.06±0.4μM. Virtual screening of the BITS-Pilani in-house database using the crystal structure of the MTB CM bound transition state intermediate (PDB: 2FP2) as framework identified carvacrol as a potential lead. Further various carvacrol derivatives were evaluated in vitro for their ability to inhibit MTB CM enzyme, whole cell MTB and cytotoxicity as steps toward the derivation of structure-activity relationships (SAR) and lead optimization.
- Alokam, Reshma,Jeankumar, Variam Ullas,Sridevi, Jonnalagadda Padma,Matikonda, Siddharth Sai,Peddi, Santosh,Alvala, Mallika,Yogeeswari, Perumal,Sriram, Dharmarajan
-
p. 547 - 554
(2014/08/05)
-
- HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS
-
A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy,-CN,-C(Rc)2OH,-N(Rd)C(=X)Rc,-C(=X)N(Rc)(Rd),-S(O)m-Rc,-N(Rc)(Rd)S(O)2,-S(O)2N(R c)(Rd),-N(Re)2, aryl optionally substituted with Ra or-O-aryl optionally substituted with Ra; or B is present and is-(CH2)n-,-C(Rb)2-or-O-, or B taken together with A or Z can be-C=C(Rb)-,-C(Rb)=C-,-CH2-CH(R b)-or-CH(Rb)-CH2-; D is-O-or-S(O) m,-; E is a bond or is-(CH2)n-,-N(R d)-,-(CH2)nN(Rd)-or-N(R d)(CH2)n-; F is-C(=X)-; G is-(CH2 )n-,-N(Rd)-,-(CH2)nN(R d)-or-N(Rd)(CH2)n; J is a bond,-O-,-N(RC)C(=X)-,-C(=X)N(Rc)-,-S(O)m,-,-N(Rc)S(O)m-,-S(O)nN(Rc)-,-N(Re)-or-N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.
- -
-
Page/Page column 67-68
(2008/06/13)
-