- KINASE INHIBITORS
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There are provided compounds of formula (I), (Formula (I)) wherein R1 to R5, X1, X2, Ar, L, E, A, A1, G and G1 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
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- Cobalt-catalyzed carboxylation of propargyl acetates with carbon dioxide
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The cobalt-catalyzed carboxylation of propargyl acetates with CO2 (1 atm) is described. The reaction proceeds at room temperature in the presence of Mn powder as a reducing reagent. Various propargyl acetates are converted to the corresponding carboxylic acids in good to high yields.
- Nogi, Keisuke,Fujihara, Tetsuaki,Terao, Jun,Tsuji, Yasushi
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p. 13052 - 13055
(2015/02/19)
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