In support of a program to develop a treatment for chemotherapy-induced nausea and vomiting, two isotopically labeled forms of neurokinin-1 receptor antagonist aprepitant have been synthesized. A [14C]-labeled version was synthesized for use in metabolism studies, while a [13C 2, 15N3]-labeled version was synthesized for use in a study to determine the bioavailability of the final market image. Both syntheses utilized labeled chloroacetonitrile which was synthesized in two steps from labeled potassium cyanide. Copyright
Elmore, Charles S.,Dean, Dennis C.,Zhang, Yong,Mellilo, David G.