- 1-CYANO-PYRROLIDINE DERIVATIVES AS INHIBITORS OF USP30.
-
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylatingenzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein R1, R 2, R 3, m, L and X are as defined herein.
- -
-
Page/Page column 60
(2018/02/03)
-
- 2,3-Dihydrobenzofuran-2-ones: A New Class of Highly Potent Antiflammatory Agents
-
A series of 2,3-dihydrobenzofuran-2-one analogues of the mold metabolite wortmannin, which is a powerful antiimflammatory compound, was synthesized.Most of these compounds were tested for their ability to inhibit the carrageenin paw edema and the adjuvant
- Closse, Annemarie,Haefliger, Walter,Hauser, Daniel,Gubler, Hans Ulrich,Dewald, Beatrice,Baggiolini, Marco
-
p. 1465 - 1471
(2007/10/02)
-