- Preparation method of tris (hydroxymethyl) methylglycine
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The invention relates to the technical field of biological buffering agents, and discloses a preparation method of tris (hydroxymethyl) methylglycine, which comprises the following preparation steps: reacting a compound I with a compound A to obtain a compound II; the compound II is subjected to at least one of a hydrolysis reaction, an oxidation reaction and an acid-base treatment reaction to obtain a tri(hydroxymethyl)methylglycine crude product, and the tri(hydroxymethyl)methylglycine crude product is purified to obtain a tri(hydroxymethyl)methylglycine refined product. The raw materials used in the preparation method are low in cost, operation is easy, the obtained product is high in purity, the yield of the product is increased, the application cost of the product is reduced, the obtained product meets the requirements for the purity, the impurity content, the cost and the like of the product in the field of biological buffering agents, and the method is suitable for industrial production, and the method is suitable for application in the field of biological buffers.
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Paragraph 0077-0089
(2022/01/10)
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- Stabilizing labeled antibody using amino acids
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The present invention relates to a method for stabilizing a labeled antibody in a solution, in which the labeled antibody is stabilized by allowing the labeled antibody to be present together with at least one of amino acid and a derivative thereof in the solution.
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- Therapeutically active complexes of tetracyclines
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Tri-tetracyclines are complexes of tetracyclines with an amino compound containing per molecule at least a tris (hydroxyalkyl) group and at least a primary or secondary amino group in a molar excess in respect to the tetracycline compound. The complexes have high water solubility and are particularly useful for parenteral administration.
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