- PYRIMIDINES USEFUL AS MODULATORS OF VOLTAGE-GATED ION CHANNELS
-
The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
- -
-
-
- Studies on the synthesis of the derivatives of 5-(dihydroxyboryl)-cytosines and -isocytosines
-
Boron derivatives of isocytosine, containing a dihydroxyboryl group in the 5-position, have been prepared for the first time. Reaction of appropriate pyrimidines with n-butyllithium and subsequent boronation at -100°C with triethylborate, followed by catalytic hydrogenation, gave hydrolytically stable N,N-dimethyl-5-(dihydroxyboryl)isocytosine 8a and N-methyl-5-(dihydroxyboryl)isocytosine 8b. Theoretical calculations suggest that the corresponding boron derivatives of cytosine cannot be obtained as thermodynamically stable compounds.
- Wojtowicz-Rajchel, Hanna,Suchowiak, Marek,Fiedorow, Piotr,Golankiewicz, Krzysztof
-
p. 841 - 845
(2007/10/03)
-