571202-87-4Relevant articles and documents
CELL-PENETRATING FLUORESCENT DYES WITH SECONDARY ALCOHOL FUNCTIONALITIES
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Page/Page column 31; 65; 66, (2018/03/28)
The invention relates to novel cell-penetrating fluorescent dyes with with secondary alcohol functionalities having one of the following general formulae I-III and 4: The invention also relates to the use of these compounds for optical microscopy and imaging techniques.
Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED
Butkevich, Alexey N.,Belov, Vladimir N.,Kolmakov, Kirill,Sokolov, Viktor V.,Shojaei, Heydar,Sidenstein, Sven C.,Kamin, Dirk,Matthias, Jessica,Vlijm, Rifka,Engelhardt, Johann,Hell, Stefan W.
supporting information, p. 12114 - 12119 (2017/09/14)
Hydroxylated rhodamines, carbopyronines, silico- and germanorhodamines with absorption maxima in the range of 530–640 nm were prepared and applied in specific labeling of living cells. The direct and high-yielding entry to germa- and silaxanthones tolerates the presence of protected heteroatoms and may be considered for the syntheses of various sila- and germafluoresceins, as well as -rhodols. Application in stimulated emission depletion (STED) fluorescence microscopy revealed a resolution of 50–75 nm in one- and two-color imaging of vimentin-HaloTag fused protein and native tubulin. The established structure–property relationships allow for prediction of the spectral properties and the positions of spirolactone/zwitterion equilibria for the new analogues of rhodamines, carbo-, silico-, and germanorhodamines using simple additive schemes.
Total syntheses of murrayamine E, I, and K
Schuster, Christian,Julich-Gruner, Konstanze K.,Schnitzler, Heinrich,Hesse, Ronny,J?ger, Anne,Schmidt, Arndt W.,Kn?lker, Hans-Joachim
, p. 5666 - 5673 (2015/06/16)
We describe efficient synthetic routes to murrayamine A (mukoenine C), O-methylmurrayamine A, mahanine, O-methylmahanine, and murrayamine D and the first total syntheses of murrayamine E, I, and K. Key steps are a palladium-catalyzed construction of the carbazole framework and an annulation of the pyran ring, which is either catalyzed by phenylboronic acid or promoted by a Lewis acid.
Synthesis of prenyl- and geranyl-substituted carbazole alkaloids by DIBAL-H promoted reductive pyran ring opening of dialkylpyrano[3,2-a]carbazoles
Hesse, Ronny,Kataeva, Olga,Schmidt, Arndt W.,Knoelker, Hans-Joachim
supporting information, p. 9504 - 9509 (2014/08/18)
The DIBAL-H promoted reductive pyran ring opening of dialkylpyrano[3,2-a] carbazoles provides a direct access to a broad range of prenyl- and geranyl-substituted carbazoles. Formation of a pyran ring followed by reductive ring opening represents a new met
Total synthesis of 7- and 8-oxygenated pyrano[3,2-a]carbazole and pyrano[2,3-a]carbazole alkaloids via boronic acid-catalyzed annulation of the pyran ring
Julich-Gruner, Konstanze K.,Kataeva, Olga,Schmidt, Arndt W.,Knoelker, Hans-Joachim
supporting information, p. 8536 - 8540 (2014/07/21)
The boronic acid-catalyzed annulation of citral opens up a short route to oxygenated cyclized monoterpenoid pyranocarbazole alkaloids. Thus, murrayamine-D is available in only three steps and 55% overall yield from the corresponding carbazole precursor.
Synthesis of macrocyclic ketones exploiting palladium-catalyzed activation of carboxylic acids as an enabling step
Kapdi, Anant R.,Fairlamb, Ian J. S.
, p. 961 - 964 (2013/06/27)
The novel synthesis of macrocyclic arylketones via palladium-catalyzed cross-coupling of arylboronic acids and carboxylic acids, activated by the treatment with di(N-succinimidyl) carbonate, is disclosed. This allows the high yielding synthesis of various
PHENOXYALKANOIC ACID COMPOUND
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Page/Page column 37, (2008/06/13)
The present invention provides a compound represented by the formula: wherein each symbol is as defined in the specification. Since the compound of the present invention has superior hypoglycemic action and superior hypolipidemic action, it is useful as an agent for the prophylaxis or treatment of diabetes, hyperlipidemia, impaired glucose tolerance and the like.
Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands
Shah, Nilesh,Scanlan, Thomas S.
, p. 5199 - 5203 (2007/10/03)
A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) function.
Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof
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, (2008/06/13)
The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal